血液透析对急诊脓毒症患者炎性指标的影响

Influence of Hemodialysis on Inflammatory Index in Emergency Sepsis Patients

目的:分析急性脓毒症患者治疗中应用血液透析对炎性指标的影响。方法:选取2019年4月—2022年2月于江南大学附属医院急诊医学科接受治疗的60例急性脓毒症患者为研究对象,采用硬币法分为对照组与研究组,各30例。对照组采用常规治疗,研究组采用血液透析。观察两组患者治疗前及治疗第7天的生命体征、白细胞计数、炎性因子水平。结果:治疗前,两组体温、心率、呼吸频率、平均动脉压及白细胞计数水平比较,差异无统计学意义(P>0.05);治疗第7天,两组体温、心率、呼吸频率及白细胞计数水平均低于治疗前,且研究组体温、白细胞计数低于对照组,差异有统计学意义(P<0.05);两组平均动脉压水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组患者治疗第7天心率、呼吸频率比较,差异无统计学意义(P>0.05)。治疗前,两组C反应蛋白、降钙素原、肿瘤坏死因子α、白细胞介素6水平比较,差异无统计学意义(P>0.05);治疗第7天,两组患者C反应蛋白、降钙素原、肿瘤坏死因子α、白细胞介素6水平均低于治疗前,且研究组C反应蛋白、肿瘤坏死因子α、白细胞介素6水平低于对照组,差异有统计学意义(P<0.05);两组治疗第7天降钙素原比较,差异无统计学意义(P>0.05)。结论:在对急诊脓毒症患者展开治疗期间,选择血液透析治疗方式,可降低患者炎性反应,利于改善预后效果。

Objective:To analyze the influence of hemodialysis on inflammatory index in the treatment of emergency sepsis patients.Methods:From April 2019 to February 2022,60 patients with emergency sepsis who received treatment in the Department of Emergency Medicine of the Affiliated Hospital of Jiangnan University were selected as the study subjects.They were divided into the control group and study group by using the corn method,with 30 cases in each group.The control group received routine treatment and the study group received hemodialysis.The vital signs,white blood cell count,and inflammatory factor levels of the two groups were observed before treatment and on Day 7 of treatment.Results:Before treatment,there were no significant differences in body temperature,heart rate,respiratory rate,mean arterial pressure and white blood cell count between the two groups(P>0.05).On Day 7 of treatment,the body temperature,heart rate,respiratory rate and white blood cell count levels in the two groups were lower than those before treatment,and the body temperature and white blood cell count in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The mean arterial pressure level in the two groups was higher than that before treatment,and the study group was higher than the control group,and the difference was statistically significant(P<0.05).There was no significant difference in heart rate and respiratory rate on Day 7 of treatment between the two groups(P>0.05).Before treatment,there was no significant difference in the levels of C-reactive protein,procalcitonin,tumor necrosis factor α and interleukin 6 between the two groups(P>0.05).On Day 7 of treatment,the levels of C-reactive protein,procalcitonin,tumor necrosis factorαand interleukin 6 in the two groups were lower than those before treatment,and the levels of C-reactive protein,tumor necrosis factorαand interleukin 6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in procalcitonin on Day 7 of treatment between the two groups(P>0.05).Conclusion:During the treatment of emergency sepsis patients,the hemodialysis treatment method can reduce the inflammatory reaction of patients and is conductive to improving prognosis effect.