阿仑膦酸钠联合阿托伐他汀治疗中老年骨质疏松症的效果分析

Effect Analysis of Alendronate Sodium Combined with Atorvastatin in Treatment of Middle-aged and Elderly Osteoporosis

目的:探讨阿仑膦酸钠联合阿托伐他汀治疗中老年骨质疏松症的效果和安全性。方法:选取2021年2月—2022年12月丰台社区卫生服务中心收治的108例中老年骨质疏松症患者为研究对象,根据随机数字表法分为两组,各54例。对照组应用钙尔奇D3片和阿仑膦酸钠,研究组在对照组基础上应用阿托伐他汀。对比两组治疗效果、不良反应发生情况、骨代谢指标、骨密度、生活质量。结果:研究组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组Ⅰ型胶原C端肽片段(CTX-1)、Ⅰ型前胶原N端肽(PINP)、成纤维生长因子23(FGF23)水平与治疗前相比均得到显著改善,而研究组CTX-1、PINP水平高于对照组,研究组FGF23水平低于对照组,差异有统计学意义(P<0.05);治疗后,前臂、腰椎正位、股骨颈骨密度高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组生理、心理、环境、社会关系评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对于中老年骨质疏松症患者应用阿仑膦酸钠联合阿托伐他汀,可提高抗骨质疏松的疗效,改善骨密度和骨代谢,提升生活质量,安全性良好。

Objective:To explore the efficacy and safety of alendronate sodium combined with atorvastatin in the treatment of middle-aged and elderly osteoporosis.Methods:A total of 108 middle-aged and elderly patients with osteoporosis who were admitted to Fengtai Community Health Service Center from February 2021 to December 2022 were selected as the study subjects.They were divided into two groups according to the random number table method,with 54 cases in each group.The control group was treated with calcium carbonate and vitamin D3 tablets+alendronate sodium,and the study group was treated with atorvastatin on the basis of control group.The treatment effect,adverse reactions,bone metabolism index,bone mineral density and quality of life of the two groups were compared.Results:The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of C-terminal telopeptide of type 1 collagen(CTX-1),N-terminal propeptide of type Ⅰ procollagen(PINP)and fibroblast growth factor 23(FGF23)in two groups were significantly improved compared with those before treatment,and the levels of CTX-1 and PINP in the study group were higher than those in the control group,and the levels of FGF23 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the bone mineral density of forearm,lumbar spine and femoral neck was higher than that before treatment,the level in the study group was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in the two groups were higher than those before treatment,and the scores in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For middle-aged and elderly patients with osteoporosis,the combination of alendronate sodium and atorvastatin can improve the anti-osteoporosis effect,improve bone mineral density and bone metabolism,improve the quality of life,and have good safety.