瞬时弹性成像评估不同程度脂肪肝的临床价值

Clinical value of FibroTouch in the evaluation of different degrees of fatty liver

目的探讨瞬时弹性成像(FibroTouch)对不同程度脂肪肝的评估价值。方法选取120例不同程度脂肪肝患者(轻、中、重度组分别为59、45、16例),均行FibroTouch检测获得受控衰减参数和肝脏硬度;收集各组体质量指数、脂肪变性程度、甘油三酯、气球样变等一般资料;比较各组上述参数的差异。应用多元线性回归分析受控衰减参数的影响因素。结果轻、中、重度组受控衰减参数分别为(245.56±17.62)dB/m、(286.97±23.49)dB/m和(342.82±20.55)dB/m,肝脏硬度分别为(4.6±0.9)kPa、(5.2±0.9)kPa、(9.0±1.3)kPa,差异均有统计学意义(均P<0.05);轻、中、重度组受控衰减参数及肝脏硬度均依次增大,两两比较差异均有统计学意义(均P<0.05)。各组体质量指数、脂肪变性程度、甘油三酯、气球样变比较差异均有统计学意义(均P<0.05)。多元线性回归分析显示,体质量指数、脂肪变性程度、甘油三酯、气球样变、肝脏硬度均为受控衰减参数的影响因素(均P<0.05)。结论FibroTouch可以准确评估不同程度脂肪肝,具有较好的临床应用价值。

Objective To explore the clinical value of FibroTouch in the evaluation of different degrees of fatty liver.Methods Totally 120 patients with different degrees of fatty liver(mild,moderate and severe group were 59,45,16 cases)were selected.All patients underwent FibroTouch to obtain controlled attenuation parameters and liver hardness.The body mass index,degree of fatty change,triglyceride,ballooning change of all group were obtained,the differences of above parameters in each group were compared.Multiple linear regression analysis was used to analyze the influencing factors of the controlled attenuation parameters.Results The controlled attenuation parameters in the mild,moderate and severe group were(245.56±17.62)dB/m,(286.97±23.49)dB/m and(342.82±20.55)dB/m,respectively,the liver hardness were(4.6±0.9)kPa,(5.2±0.9)kPa,(9.0±1.3)kPa,respectively,with statistically significant differences(all P<0.05).The controlled attenuation parameter and liver hardness increased sequentially in the mild,moderate and severe group,there were significant differences in pairwise comparison(all P<0.05).Multiple linear regression analysis showed that the influencing factors of the controlled attenuation parameter were body mass index,degree of fatty change,triglyceride,ballooning change and liver hardness(all P<0.05).Conclusion FibroTouch can accurately evaluate different degrees of fatty liver and has good clinical application value.