长时程亚低温治疗在重型颅脑损伤术后患者中的应用

Application of Long-Term Mild Hypothermia Therapy in Patients after Severe Craniocerebral Injury Surgery

目的分析长时程亚低温治疗在重型颅脑损伤术后患者中的应用效果。方法将我院收治的88例重型颅脑损伤患者根据其术后亚低温治疗方式不同分为观察组(n=44)和对照组(n=44)。对照组行短时程亚低温治疗,观察组行长时程亚低温治疗。比较两组患者的神经功能、肢体功能,血清NSE、MBP水平及术后28 d死亡率。结果治疗后,观察组的NIHSS评分及血清NSE、MBP水平低于对照组,FMA评分高于对照组(P<0.05)。观察组术后28 d死亡率低于对照组(P<0.05)。结论长时程亚低温治疗可明显改善重型颅脑损伤术后患者的神经功能和肢体功能,降低其血清NSE、MBP水平及死亡率。

Objective To analyze the application effect of long-term mild hypothermia therapy in patients after severe craniocerebral injury surgery.Methods 88 patients with severe craniocerebral injury admitted to our hospital were divided into observation group(n=44)and control group(n=44)according to the postoperative mild hypothermia treatment methods.The control group received short-term mild hypothermia therapy,and the observation group received long-term mild hypothermia therapy.The neurological function,limb function,serum NSE and MBP levels,and mortality rate at 28 days after operation were compared between the two groups.Results After treatment,the NIHSS score and the serum NSE and MBP levels of the observation group were lower than those of the control group,and the FMA score was higher than that of the control group(P<0.05).The mortality rate at 28 days after operation of the observation group was lower than that of the control group(P<0.05).Conclusions Long-term mild hypothermia therapy can significantly improve the neurological function and limb function,and reduce the serum NSE and MBP levels and mortality rate in patients after severe craniocerebral injury surgery.