静脉注射丙种球蛋白对新生儿败血症的临床疗效及血清炎性因子水平的影响

Clinical Efficacy of Intravenous Injection of Gamma Globulin for Neonatal Sepsis and the Impact on Serum Inflammatory Factor Levels

目的探讨静脉注射丙种球蛋白对新生儿败血症的临床疗效及血清炎性因子水平的影响。方法选取2020年1月至2021年12月我院收治的70例败血症新生儿,随机分为两组各35例。对照组静脉注射头孢噻肟钠,观察组在对照组基础上静脉注射丙种球蛋白,比较两组患儿的临床疗效及血清炎性因子水平。结果观察组治疗总有效率为94.29%,高于对照组的74.29%(P<0.05)。治疗后,两组的血清CRP、TNF-α、IL-6、PCT水平均低于治疗前,且观察组血清CRP、TNF-α、IL-6及PCT水平均低于对照组(P<0.05)。结论静脉注射丙种球蛋白可提高新生儿败血症的临床疗效,降低患儿的血清炎性因子水平,值得临床推广应用。

Objective To explore the clinical efficacy of intravenous injection of gamma globulin for neonatal sepsis and the impact on serum inflammatory factor levels.Methods 70 neonates with sepsis admitted to our hospital from January 2020 to December 2021 were selected and randomly divided into two groups,with 35 cases in each group.The control group was given intravenous injection of cefotaxime sodium,and the observation group was given intravenous injection of gamma globulin on the basis of the control group.The clinical efficacy and serum inflammatory factor levels were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.29%,higher than 74.29% in the control group(P<0.05).After treatment,the serum CRP,TNF-α,IL-6 and PCT levels of the two groups were lower than those before treatment,and the serum CRP,TNF-α,IL-6 and PCT levels of the observation group were lower than those of the control group(P<0.05).Conclusions Intravenous injection of gamma globulin can improve the clinical efficacy of neonatal sepsis and reduce the serum inflammatory factor levels,which is worthy of clinical promotion and application.