摘要
组织激肽释放酶8(KLK8)与中枢神经系统的联系极为紧密,通过改变突触间的黏附关系和细胞外基质分子从而改变突触形态,调节突触可塑性,最终参与多种神经系统疾病的病理过程。本文针对KLK8的生理特性,对其在神经系统疾病如情绪障碍、阿尔茨海默病、癫痫、多发性硬化中的作用与发病机制进行综述。期待能够为神经系统疾病诊断和预后提供理论依据,为此类疾病的研究提供方向。
Kallikrein 8(KLK8)is closely related to the central nervous system and is involved in the pathological processes of many neurological diseases by altering inter-synaptic adhesion relationships and extracellular matrix molecules thereby modifying synaptic morphology and regulating synaptic plasticity.In this paper,we review the role and pathogenesis of KLK8 in neurological disorders such as dysthymic disorders,Alzheimer s disease,epilepsy,and multiple sclerosis with respect to its physiological properties.It is expected to provide a theoretical basis for the diagnosis and prognosis of neurological diseases and provide directions for the research ofsuch diseases.
作者
刘诗雨
刘宇健
LIU Shiyu;LIU Yujian(School of Kinesiology,the Key Laboratory of Exercise and Health Sciences of Ministry of Education,Shanghai Frontiers Science Research Base of Exercise and Metabolic Health,Shanghai University of Sport,Shanghai 200438,China)
出处
《基础医学与临床》
2023年第4期660-664,共5页
Basic and Clinical Medicine
