摘要
星形胶质细胞应对多种中枢神经系统(CNS)损伤并活化为反应性星形胶质细胞,通过神经保护或神经毒性作用影响CNS的组织修复和神经炎性疾病的发生和发展。反应性星形胶质细胞的发生机制主要与其表型转化及下游炎性通路的激活相关。探索反应性星形胶质细胞的特征及其对CNS炎性疾病的调控机制可能为CNS炎性疾病的发病机制提供新见解和潜在干预靶点。
Astrocytes respond to various forms of central nervous system(CNS)damage which are activated to be reactive astrocytes and participate in tissue repairing,initiation and progression of neuroinflammatory diseases in CNS through neuroprotective or neurotoxic effects.The mechanism of reactive astrocytes is mainly related to their phenotypic transformation and activation of downstream inflammatory pathways.Exploring the characterization of reactive astrocytes and the underling mechanisms may provide unique insights into the pathogenesis of neuroinflammatory diseases and to identify potential targets of clinical treatment.
作者
李立亚
秦霈
LI Liya;QIN Pei(Department of Anesthesiology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116007;Department of Anesthesiology,Xi'an Children's Hospital,Xi'an 710003,China)
出处
《基础医学与临床》
2023年第4期665-668,共4页
Basic and Clinical Medicine
基金
国家自然科学基金青年项目(81901205)。
