血管周围脂肪组织炎性反应促进动脉粥样硬化作用机制的研究进展

Research progress on the mechanism of perivascular adipose tissue inflammation promoting atherosclerosis

动脉粥样硬化严重威胁人类生命与健康。高血压、高脂血症病理条件下,血管周围脂肪组织(PVAT)中免疫细胞亚型紊乱、棕色脂肪“白色化”、氧化应激反应等病理改变可促进PVAT炎性反应。PVAT炎性反应可通过引起促炎及抑炎性脂肪因子分泌紊乱、抑制PVAT中细胞自噬、诱导动脉外膜滋养血管形成等机制,促进内皮细胞功能损害、动脉内膜单核-巨噬细胞浸润、动脉粥样硬化斑块形成、易损斑块形成等病理过程,从而促进动脉粥样硬化起病及进展。

Atherosclerosis is harmful to human health.Under pathological conditions including hypertension and hyperlipidemia,increased levels of pro-inflammatory immunocytes in perivascular adipose tissue(PVAT),“whitening”of brown adipose tissue,and oxidative stress could promote the development of PVAT inflammation.PVAT inflammation could induce various crucial stages of atherosclerosis by disturbing secretion of inflammatory and anti-inflammatory adipokines,inhibiting PVAT cell autophagy,and activating angiogenesis in arterial adventitia,thereby promoting the onset and progression of atherosclerosis.