抗VEGF联合超声睫状体成形术治疗新生血管性青光眼

Treatment of neovascular glaucoma by anti-vascular endothelial growth factor combined with ultrasonic ciliary plasty

目的:探讨超声睫状体成形术(UCP)联合抗VEGF注射在治疗新生血管性青光眼(NVG)患者中的临床疗效及安全性的研究。方法:选取2020-09/2021-09于蚌埠医学院第一附属医院就诊的NVG患者30例30眼,入院后所有患者术眼均注射抗VEGF药物(雷珠单抗),术后再从中随机选取15例行UCP治疗(UCP组),另15例行小梁切除术(小梁组)。术后随访时长为10mo,每次随访时,比较两组患者术眼眼压下降程度,评估术眼疼痛程度的变化及相关并发症的发生。结果:UCP组和小梁组眼压及患眼疼痛程度均较术前有明显下降,UCP组并发症相较小梁组少。结论:UCP联合抗VEGF注射能够有效地控制NVG患者眼压及疼痛程度,且并发症较少安全性高。

AIM:To investigate the clinical efficacy and safety of ultrasonic ciliary plasty(UCP)combined with injection of anti-vascular endothelial growth factor(VEGF)in the treatment of neovascular glaucoma(NVG).METHODS:A total of 30 NVG patients(30 eyes)admitted to the First Affiliated Hospital of Bengbu Medical College from September 2020 to September 2021 were selected.After admission,all the eyes of the patients were injected with anti-VEGF drug(ranibizumab).After surgery,15 patients were randomly selected for UCP treatment(UCP group),and the other 15 patients received trabeculectomy(trabeculectomy group).During the 10mo postoperative follow-up,the decrease of intraocular pressure was compared between the two groups and the changes of the degree of ocular pain and the occurrence of related complications were evaluated at each follow-up visit.RESULTS:The intraocular pressure and pain degree of the UCP and trabeculectomy groups were significantly lower than those before operation,and the complication probability of the UCP group was less than that of the trabeculectomy group.CONCLUSION:With fewer complications and high safety,UCP combined with anti-VEGF injection can effectively control intraocular pressure and pain in NVG patients.