新型角膜生物力学参数在不同程度近视眼中的特性分析

Characteristics of new corneal biomechanical parameters in different degrees of myopia

目的:研究不同程度近视眼的新型角膜生物力学参数特性,并分析新型参数角膜材料硬度指数(SSI)的相关性。方法:横断面研究,选取2021-10/11就诊于大理大学第一附属医院不同程度近视成人患者366例718眼,年龄18~50岁,等效球镜度(SE)-0.50~-16.75D。采用IOL Master测量眼轴长度(AL),可视化角膜生物力学分析仪(Corvis ST)测量新型角膜生物力学参数及中央角膜厚度(CCT)和眼压(IOP)。按照SE将受检者分为低度近视、中度近视、高度近视组。数据采用方差分析及Pearson相关进行分析。结果:各组间最薄点角膜厚度与水平方向厚度变化率比值(ARTh)、SSI均有差异(P<0.001),其余角膜生物力学参数均无差异(P>0.05)。SSI与年龄(r=0.102,P=0.006)、SE(r=0.361,P<0.001)、IOP(r=0.175,P<0.001)、CCT(r=0.098,P=0.009)、SPA1(r=0.182,P<0.001)呈正相关,与AL(r=-0.331,P<0.001)、IR(r=-0.545,P<0.001)呈负相关,与其他角膜生物力学参数均无相关性(P>0.05)。结论:随着近视度数的增高及眼轴的增长,SSI值变小,角膜硬度降低,SSI可能是未来近视研究有用的角膜生物力学指标。

AIM:To study the characteristics of new corneal biomechanical parameters in different degrees of myopia and analyze the correlation of the new parameter stress-strain index(SSI).METHODS:A cross-sectional study was conducted on 366 adult patients(718 eyes)with different degrees of myopia who received treatment at the First Affiliated Hospital of Dali University from October 2021 to November 2021,aged 18-50 years,and the spherical equivalent(SE)was-0.50~-16.75D.The axial length(AL)of the eye was measured by IOL master,and the new corneal biomechanical parameters,central corneal thickness(CCT)and intraocular pressure(IOP)were measured by corneal visualization Scheimpflug technology(Corvis ST).The subjects were categorized into low myopia,moderate myopia and high myopia groups according to SE.The data were analyzed by ANOVA and Pearson correlation.RESULTS:The ratio of the thinnest corneal thickness to horizontal thickness change rate(ARTh)and SSI were statistically significant(P<0.001),while the remaining parameters were not statistically significant(P>0.05).SSI was positively correlated with age(r=0.102,P=0.006),SE(r=0.361,P<0.001),IOP(r=0.175,P<0.001),CCT(r=0.098,P=0.009),SPA1(r=0.182,P<0.001),negatively correlated with AL(r=-0.331,P<0.001),IR(r=-0.545,P<0.001)and had no correlation with other corneal biomechanical parameters(P>0.05).CONCLUSION:With the increase of myopia degree and the elongation of the axial length,the SSI value becomes smaller and the corneal hardness decreases.SSI may be a helpful corneal biomechanical indicator for future research on myopia.