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A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues 被引量:2

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摘要 The newly emerged Omicron(B.1.1.529)variant of SARS-CoV-2 is quickly overtaking the Delta variant and becoming the dominant strain around the world due to its enhanced transmissibility and high immune escape potential[1,2].Compared to the Wuhan strain,the Omicron variant carries 37 spike mutations,of which 15 are within the receptor-binding domain(RBD)(Fig.1A).A high mutation rate is associated with remarkable resistance to current vaccines and RBD-specific antibody therapeutics[2,3,4].
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2022年第5期647-649,共3页 中国免疫学杂志(英文版)
基金 supported by the Ministry of Science and Technology of China (2018YFA0507402) the National Natural Science Foundation of China (32100123,32100751,and 82041015).
关键词 RESIDUES BECOMING OMI
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