唾液酸酶1、Toll样受体4在子宫内膜癌中的表达及与患者临床特征和预后的关系

Expression of neuraminidase 1 and Toll-like receptor 4 in endometrial carcinoma and their relationship with clinical characteristics and prognosis of patients

目的探讨唾液酸酶1(NEU1)、Toll样受体4(TLR4)在子宫内膜癌中的表达及与患者临床特征和预后的关系。方法收集61例子宫内膜癌患者的子宫内膜癌组织和癌旁组织。比较子宫内膜癌组织和癌旁组织中NEU1、TLR4的表达情况,比较不同临床特征子宫内膜癌患者子宫内膜癌组织中NEU1、TLR4的表达情况。采用Kaplan-Meier法绘制生存曲线,分析NEU1、TLR4表达情况与子宫内膜癌患者预后的关系。采用多因素Cox回归模型分析子宫内膜癌患者预后的影响因素。结果子宫内膜癌组织中NEU1、TLR4阳性表达率均明显低于癌旁组织,差异均有统计学意义(P<0.01)。有淋巴结转移、国际妇产科联盟(FIGO)分期为Ⅲ~Ⅳ期、肌层浸润深度≥1/2子宫内膜癌患者子宫内膜癌组织中NEU1、TLR4阳性表达率均低于无淋巴结转移、FIGO分期为Ⅰ~Ⅱ期、肌层浸润深度<1/2的患者,差异均有统计学意义(P<0.05)。NEU1阴性表达患者的5年累积生存率为64.60%,低于NEU1阳性表达患者的93.80%(P<0.05);TLR4阴性表达患者的5年累积生存率为61.40%,低于TLR4阳性表达患者的91.70%(P<0.05)。FIGO分期为Ⅲ~Ⅳ期是子宫内膜癌患者预后的独立危险因素(P<0.05),NEU1阳性、TLR4阳性均是子宫内膜癌患者预后的独立保护因素(P<0.05)。结论NEU1、TLR4在子宫内膜癌组织中的阳性表达率均较低,且与患者的淋巴结转移情况、FIGO分期、肌层浸润深度及预后有关,有望成为子宫内膜癌的诊疗靶点。

Objective To investigate the expression of neuraminidase 1(NEU1)and Toll-like receptor 4(TLR4)in endometrial carcinoma and their relationship with clinical characteristics and prognosis of patients.Method The endometrial carcinoma tissues and adjacent tissues of 61 patients with endometrial cancer were collected.The expression of NEU1 and TLR4 in endometrial carcinoma tissues and adjacent tissues,and endometrial carcinoma tissues of patients with different clinical characteristics were compared.Kaplan-Meier method was used to draw survival curve and analyze the relationship of NEU1 and TLR4 expression with the prognosis of endometrial carcinoma patients.Multivariate Cox regression model was used to analyze the influencing factors of prognosis in endometrial carcinoma patients.Result The positive expression rates of NEU1 and TLR4 in endometrial carcinoma tissues were significantly lower than those in adjacent tissues(P<0.01).The positive expression rates of NEU1 and TLR4 in endometrial carcinoma tissues of patients with lymph node metastasis,International Federation of Gynecology and Obstetrics(FIGO)stage III-IV,myometrial invasion depth≥1/2 were lower than those of patients without lymph node metastasis,FIGO stage I-II,myometrial invasion depth<1/2(P<0.05).The 5-year cumulative survival rate of patients with NEU1 negative expression was 64.60%,lower than 93.80%of patients with NEU1 positive expression(P<0.05).The 5-year cumulative survival rate of patients with TLR4 negative expression was 61.40%,lower than 91.70%of patients with TLR4 positive expression(P<0.05).FIGO stage IIIIV was independent risk factor for prognosis of endometrial carcinoma patients(P<0.05),and NEU1 positive and TLR4 positive were independent protective factors for prognosis of endometrial carcinoma patients(P<0.05).Conclusion The positive expression rates of NEU1 and TLR4 in endometrial carcinoma tissues are relatively low,and are related to lymph node metastasis,FIGO stage,myometrial invasion depth and prognosis of patients,which are expected to become the diagnosis and treatment target of endometrial carcinoma.