分枝杆菌Ⅶ型分泌系统的结构、底物与功能

Structure, substrate and function of mycobacterium type Ⅶ secretory system

细菌分泌系统对于细菌的发育、种内和种间竞争、营养获取、毒力、生理、遗传、生态都非常重要。细菌利用分泌系统将蛋白质分泌到细胞外,也是细菌适应生境所必需的。分枝杆菌Ⅶ型分泌系统及其底物与结核分枝杆菌致病密切相关,笔者将对Ⅶ型分泌系统的组成、结构、底物和功能进行介绍,尤其是与宿主相互作用中的功能,以期为研发结核病新的控制措施提供基础。

Bacterial secretion system is very important for bacterial development,intraspecific and interspecific competition,nutrition acquisition,virulence,physiology,genetics and ecology.Bacteria use the secretion system to secrete proteins outside the cell,which is also necessary for bacteria to adapt to the environment.Mycobacterium typeⅦsecretory system and its substrate are closely related to the pathogenesis of Mycobacterium tuberculosis.This article introduces the composition,structure,substrate and function of typeⅦsecretion system,especially its function in interaction with host,hoping to provide a basis for the research and development of new control measures for tuberculosis.