红藤败酱液结合结肠水疗仪保留灌肠治疗放射性肠炎的临床效果研究

Clinical application of Hongteng Baijiang liquid combined with colon hydrotherapy instrument for retention enema in the treatment of radiation enteritis

目的:探讨红藤败酱液结合结肠水疗仪保留灌肠治疗放射性肠炎(RE)的临床效果。方法:选取2021年4月—2022年4月我院收治的RE患者113例,按照随机数表法分为对照组57例和观察组56例,对照组予结肠水疗仪行常规肠道水疗,观察组则予红藤败酱液结合结肠水疗仪保留灌肠治疗,比较两组治疗效果、治疗前后中医证候积分、放射损伤程度、炎性因子及免疫功能变化。结果:治疗10 d后,观察组总有效率明显高于对照组(P<0.05);观察组中医证候积分较对照组明显降低(P<0.05);疗程结束后随访1个月,观察组治疗后0~I级放射损伤程度占比高于对照组(P<0.05),末次随访时,两组放射反应症状缓解率差异无统计学意义,但观察组放射反应症状反复发生率低于对照组(P<0.05);观察组患者血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均低于对照组(P<0.05);观察组各免疫细胞因子(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平均高于对照组(P<0.05)。结论:红藤败酱液结合结肠水疗仪保留灌肠治疗RE疗效显著,可有效缓解患者临床不适症状,减轻放射损伤程度,降低放射反应症状反复发生率,降低机体炎症反应并提高机体免疫功能。

Objective To explore the clinical value of retention enema with Hongteng Baijiang liquid combined with colon hydrotherapy instrument in the treatment of radiation enteritis(RE).Methods 113 patients with RE who were treated in the hospital from April 2021 to April 2022 were divided into the control group(57 cases)and the observation group(56 cases)according to the random number table method.The control group was given routine intestinal hydrotherapy with colon hydrotherapy instrument,while the observation group adopted retention enema treatment with Hongteng Baijiang liquid combined with colon hydrotherapy instrument.The therapeutic efficacy,and changes in TCM syndromes scores,radiation damage degree,inflammatory factors and immune function before and after treatment were compared between the two groups.Results After 10 days of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The TCM syndromes scores of the observation group were significantly reduced compared with those of the control group(P<0.05).At 1 month of follow-up after the end of course,the proportion of grade 0~I radiation injury degree in the observation group after treatment was higher than that in the control group(P<0.05).At last follow-up,there was no statistical difference in the remission rate of radiation reaction symptoms between the two groups(P>0.05),but the recurrence rate of radiation reaction symptoms in the observation group was lower compared to the control group(P<0.05).Serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group(P<0.05)while the levels of immune cytokines(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))were higher than those in the control group(P<0.05).Conclusion Hongteng Baijiang liquid combined with colon hydrotherapy instrument for retention enema has a significant efficacy in the treatment of RE,and it can effectively relieve the clinical discomfort symptoms,relieve the degree of radiation damage,lower the recurrence rate of radiation reaction symptoms,reduce the body’s inflammatory response and enhance the body’s immune function.