摘要
以2-吡啶甲醛和3-吡咯-氨基硫脲合成了缩氨基硫脲配体,再与氯化铋反应合成了铋配合物。通过单晶衍射获得其单晶结构,每个铋配合物分子里面包含四个配体和四个铋中心。通过MTT实验测试了铋配合物在体外对多种癌细胞株(人膀胱癌细胞株T24、人肺癌细胞株A549、人胃癌细胞株MGC-803和人乳腺癌细胞株MDA-MB-231)的抗肿瘤活性。结果显示铋配合物展现出良好的抗肿瘤活性,且活性优于顺铂。
Thiosemicarbazone ligand was synthesized with 2-pyridinecarboxaldehyde and 3-pyrrole-thiosemicarbazide,and then the Bi(Ⅲ)complex was synthesized by reaction with bismuth chloride.The structure was obtained by single crystal diffraction,and each molecule of Bi(Ⅲ)complex contained four ligands and four Bi centers.The anti-tumor activity of the Bi(Ⅲ)complex was tested in vitro against various cancer cell lines(human bladder cancer cell line T24,human lung cancer cell line A549,human gastric cancer cell line MGC-803 and human breast cancer cell line MDA-MB-231)by MTT assay.The results showed that the Bi(Ⅲ)complex exhibited good antitumor activity and the activity was superior to that of cisplatin.
作者
盖爽爽
蒋才云
Gai Shuangshuang;Jiang Caiyun((Key Laboratory for Research and Development of Characteristic Yao,School of Food and Biochemical Engineering,Guangxi Science&Technology Normal University,Laibin 545004,China)
出处
《山东化工》
CAS
2023年第2期63-65,共3页
Shandong Chemical Industry
基金
广西高校中青年教师科研基础能力提升项目(2019KY0853,2020KY23016)。
