摘要
目的通过对帕金森病(Parkinson's disease,PD)患者运动及非运动症状的全面评估,分析影响PD患者生活质量(quality of Life,QoL)的因素。方法对161例PD患者进行一项横断面研究。通过帕金森病患者生活质量问卷(PDQ-39)评估患者的QoL。通过Hoehn-Yahr分级、国际运动障碍学会帕金森病统一评价量表(Movement Disorder Society-Unified Parkinson's Disease Rating Scale,MDS-UPDRS)等一系列量表对患者的运动症状和非运动症状进行全面的评估。通过Spearman相关分析分析PDQ-39总分与运动及非运动症状的相关性。通过多重线性回归分析影响PD患者QoL的因素。结果PDQ-39总分与嗓音障碍指数量表评分具有较强的相关性(r=0.616),与UPDRS-Ⅰ、UPDRS-Ⅱ、帕金森病疲劳程度量表、改良情感淡漠量表、老年抑郁量表、步态及摔倒问卷、进食问卷调查工具评分具有中等程度的相关性(r=0.3~0.5)。通过线性回归模型分析显示抑郁状态、步态、吞咽、嗓音障碍及性别与PD患者的QoL受损相关,影响程度从大到小分别为抑郁状态、步态、吞咽、嗓音障碍和性别。结论帕金森病患者的抑郁状态、步态、吞咽、嗓音障碍及性别是影响QoL的重要因素。吞咽和嗓音障碍与抑郁状态、步态等目前广受关注的因素一样,同样是影响PD患者QoL不可忽视的因素。
Objective Our objective was to identify factors predicting health-related quality of life(HRQoL)in patients with Parkinson's disease(PD)Methods A cross-sectional study was carried out in 161 PD patients.QoL was assessed with the PDQ-39.Motor symptoms and non-motor symptoms were evaluated by a list of assessment tools including the Hoehn and Yahr scale,The Movement Disorder Society Unified Parkinson Disease Rating Scale et al.The Spearman correlation coefficient r was used to evaluate the correlation between PDQ-39 and motor and non-motor factors.Multiple linear regression models were used to demonstrate whether the factors investigated contribute significantly to QoL.Results PDQ-39 Summary Index was highly correlated with Voice handicap index(r=0.616)and correlated at a moderate level(r=0.30-0.50)with UPDRS-I,UPDRS-II,Parkinson Fatigue Scale,Modified Apathy Evaluation Scale,Geriatric Depression Scale,Gait and Falls Questionnaire,Eating Assessment Tool Scale.Depression,gait,swallowing,voice handicap and gender were independent predictors of HRQoL in the multivariate analysis model.Depression showed to be the most consistent determinant of HRQoL,followed by gait problems,swallowing,voice handicap and gender.Conclusion Depression,gait problems,swallowing,voice handicap and gender are significant factors contributing to a poor quality of life in Parkinson's disease patients.Swallowing and voice handicap,as well as depression,gait problems that are widely recognized,are also factors that cannot be ignored.
作者
孟德涛
靳昭辉
杜文军
魏静然
齐琳
王瑞丹
房进平
苏源
方伯言
MENG Detao;JIN Zhaohui;DU Wenjun(Parkinson Medical Center,Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100144,China)
出处
《中风与神经疾病杂志》
CAS
2023年第3期253-256,共4页
Journal of Apoplexy and Nervous Diseases
基金
科技部国家重点研发计划(No.2018YFC0115405)
首都医科大学附属北京康复医院科技发展专项(2021-005)。
关键词
帕金森病
运动症状
非运动症状
生活质量
Parkinson's disease
Motor symptoms
Non-motor symptoms
Health-related quality of life