结节性红斑患者皮损处CD68和VEGF的表达

Expression of CD68 and VEGF in Skin Lesion of Erythema Nodosum Patients

目的 研究结节性红斑皮损中CD68和VEGF的表达情况,探讨上述因素在其发病中的作用机理。方法采用Max Vision TM免疫组织化学染色法检测49例结节性红斑患者皮损(疾病组)及10例正常皮肤组织(对照组)CD68和VEGF分子的表达情况。结果 疾病组CD68阳性表达率为95.92%,显著高于正常组CD68阳性表达率(60.00%),差异有统计学意义(P<0.01);疾病组VEGF阳性表达率为95.92%,显著高于正常组VEGF阳性表达率(60.00%),差异有统计学意义(P<0.01)。结论 CD68和VEGF在EN皮损处的高表达,提示EN皮损处有大量处于激活状态的炎细胞浸润、聚集,引起血管内皮细胞损伤,考虑炎症反应和内皮细胞损伤参与了结节性红斑皮损的发病。

Objective To Study the CD68 and VEGF expression in skin lesion tissue and their functions in pathogenesis of the erythema nodosum.Methods The expression of CD68 and VEGF in the skin lesions of 49 cases of erythema nodosum patients(disease group)and 10 cases of normal human(control group)were detected by MaxVision TM immunohistochemical staining method.Results Compared with the normal contol group(60.00%),the positive expression rate of CD68 in disease group(95.92%)was increased significantly,with statistical differences between two grouqs(P<0.01).Compared with the normal control group(60.00%),the positive egression rate of VEGF in disease group(95.92%)was increased significantly with statistical dififerences between two groups(P<0.01).Conclusion Higher expression of CD68 and VEGF in skin lesions was concluded that active inflammatory cells and injury of endothelial cell were participated in pathogenesis of erythema nodosum.