过氧化亚硝酸盐(ONOO^(-))荧光探针研究进展

Recent Progress on Peroxynitrite(ONOO^(-))Fluorescent Probes

过氧化亚硝酸盐(ONOO^(-))是一种重要的活性氧,在生命系统的生理和病理过程中起着至关重要的作用,可以抵抗免疫系统中的外来病菌。但是过量的ONOO^(-)可能会引起许多疾病,甚至是癌症。因此有效的识别和检测ONOO^(-)具有重要意义。近年来由于操作方便、选择性高、可实时性和无创性检测等优势,荧光探针法检测ONOO^(-)的研究得到了快速的发展。基于探针设计原理根据不同的荧光母体进行分类,综述了近五年来用于检测ONOO^(-)荧光探针的研究现状,评述了ONOO^(-)荧光探针的优点和不足,探讨了该领域面临的挑战,展望了ONOO^(-)荧光探针的研究和发展方向,为今后人们研究ONOO^(-)在生理病理过程中的作用提供了一定的参考价值。

Peroxynitrite(ONOO^(-))is an important reactive oxygen species that plays a crucial role in the physiological and pathological processes of the living system and is resistant to foreign bacteria in the immune system.However,excessive ONOO^(-)may cause many diseases,or even cancer.Thus the effective identification and detection of ONOO^(-)is of great importance.Recently,the detection of ONOO^(-)by fluorescent probe detection has been rapidly developed due to the advantages of easy operation,high selectivity,real-time,and non-invasive detection.This review paper classified different fluorescent matrix based on probe design principles,summarized the research status of ONOO^(-)fluorescent probes in the past five years,reviewed the advantages and disadvantages of ONOO^(-)fluorescent probes.We would also discuss the challenges faced by this field,the research and development direction of ONOO^(-)fluorescent probe,and provides guidance for the future research on the role of ONOO^(-)in the physiopathological process.