Burgess试剂在有机合成中的应用新进展

Recent Progresses on the Application of Burgess Reagent in Organic Synthesis

Burgess试剂(N-(三乙基铵磺酰)氨基甲酸甲酯)是一种温和的选择性脱水剂,可有效促进多种反应,在有机合成领域具有重要的应用价值,已广泛应用于药物及天然产物的合成。该综述简要介绍了Burgess试剂的合成方法,同时对近年来其应用进展进行了总结,主要包括醇脱水合成烯烃、酰胺脱水合成异氰或腈、诱导合成杂环化合物、醇的氧化反应、磺酸酯以及磺酰胺类化合物的合成,并对部分反应机理进行了介绍。期望Burgess试剂在官能团转化以及其他反应类型中的应用更加广阔,为有机合成领域的发展提供新的动力。

Burgess reagent(N-(triethylammonium sulfonyl)methyl carbamate)is a mild and selective dehydrating agent that can effectively promote a variety of reactions.It has important application value in organic synthesis and has been widely used in the synthesis of drugs and natural products.In this review,the synthesis methods of Burgess reagent were briefly introduced and the application progress in recent years was summarized.This review paper mainly included the synthesis of olefin by alcohol dehydration,the synthesis of isocyanide and nitrile by amide dehydration,the synthesis of induced heterocycles,the oxidation of alcohols,and the synthesis of sulfonic esters or sulfonamide compounds.Mechanisms of some reactions were introduced.It is expected that Burgess reagent will be more widely used in functional group conversion and other type of reaction,providing new impetus for the development of organic synthesis.