鹰嘴豆多肽抗疲劳活性

Study on the anti-fatigue activity of chickpea peptide

目的:提高鹰嘴豆的附加值。方法:进行小鼠负重游泳试验,测定免疫活性,分析疲劳相关生化指标。结果:负重游泳试验中,鹰嘴豆多肽喂养组小鼠游泳时间极显著长于对照组(P<0.01),鹰嘴豆多肽极显著降低了小鼠血液中尿素氮和血乳酸水平,极显著提高了肝糖原、肌糖原和胰岛素含量(P<0.01)。鹰嘴豆多肽还可显著提高超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)、乳酸脱氢酶(LDH)的活性。此外,补充鹰嘴豆多肽可以通过增加小鼠的吞噬细胞活性、刺激sIgA分泌和减少促炎细胞因子来提高免疫力。结论:鹰嘴豆多肽对小鼠具有较强的抗疲劳作用。

Objective:This study aimed to investigate the anti-fatigue activity of chickpea polypeptide and its anti-fatigue mechanism.Methods:Weight-bearing swimming test,fatigue-related biochemical index analysis and immune activity determination were analyzed in mice.Results:In the weight-bearing swimming test,the swimming time of the chickpea polypeptide-fed group was significantly longer than that of the control group(P<0.01).The test results of biochemical indicators showed that chickpea polypeptide significantly reduced the levels of urea nitrogen and blood lactic acid in the blood of mice,and also significantly increased the contents of liver glycogen,muscle glycogen and insulin(P<0.01).Chickpea polypeptide also significantly improved the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and lactate dehydrogenase(LDH).In addition,chickpea polypeptide supplementation improved the immunity by increasing phagocyte activity,stimulating sIgA secretion and reducing proinflammatory cytokines in mice.Conclusion:Chickpea polypeptide has a strong anti-fatigue effect on mice.