骨修复领域的含锰生物陶瓷材料

Manganese-containing bioceramic materials in the field of bone repair

背景:基于陶瓷的优越性能,生物陶瓷材料在骨移植和组织工程中应用广泛,但仍面临着力学强度不高、生物性功能单一的问题,无法完全满足临床骨缺损修复的应用。目的:总结和归纳生物陶瓷支架的研究现状以及锰元素掺杂对陶瓷性能的影响。方法:以“锰,微量元素,陶瓷生物材料,羟基磷灰石,磷酸三钙,3D打印,骨组织工程”为中文检索词,以“Manganese,Microelement,Ceramic biomaterial, Hydroxyapatite,Tricalcium phosphate,3D printing, Bone tissue engineering”为英文检索词,在中国知网、万方数据库、PubM ed、Web of Science等平台进行检索,检索1968年1月至2022年9月的相关文献,根据入组标准,最终纳入文献84篇。结果与结论:锰(Mn)作为一种重要的局部递送治疗活性离子,对细胞功能和骨形成具有积极刺激作用。(1)锰元素的掺杂可以极大改善陶瓷支架的力学性能,进一步增强了陶瓷材料的成骨诱导能力,赋予支架额外的抗菌特性等;(2)以含锰生物陶瓷为基础通过涂层涂敷、共价结合生物活性肽和调节掺杂元素价态等方式进一步满足骨缺损修复需求;(3)开始逐渐由单一元素掺杂向多元素掺杂转变,力求赋予支架更多的特性;(4)锰元素掺杂是一种行之有效的改性处理方式,含锰生物陶瓷通过结合先进的材料制造技术和锰的优良生物活性,在骨折及骨缺损修复方面具有很好的应用前景。

BACKGROUND:Based on the superior properties of ceramics,bioceramic materials are widely used in bone transplantation and tissue engineering.However,it still faces the problems of low mechanical strength and single biological function,which cannot fully meet the clinical application of bone defect repair.OBJECTIVE:To summarize the research status of bioceramic scaffolds and the effect of manganese doping on the performance of ceramics.METHODS:Chinese and English search terms were“manganese,microelements,ceramic biomaterials,hydroxyapatite,tricalcium phosphate,3D printing,bone tissue engineering”.Searches were carried out on CNKI,WanFang,PubMed,and Web of Science databases.Relevant articles published from January 1968 to September 2022 were retrieved.According to the inclusion criteria,84 articles were finally included.RESULTS AND CONCLUSION:Manganese,as an important locally delivering therapeutically active ion,has a positive stimulating effect on cell function and bone formation.(1)The doping of manganese elements can greatly improve the mechanical properties of ceramic scaffolds,further enhance the osteogenic induction ability of ceramic materials,and endow the scaffolds with additional antibacterial properties.(2)Based on manganese-containing bioceramics,the need for bone defect repair was further met through coating,covalently binding bioactive peptides and regulating the valence of doping elements.(3)It began to gradually change from single-element doping to multi-element doping,and strive to give the stent more characteristics.(4)Doping of manganese elements is an effective modification treatment method.Manganese-containing bioceramics have a good application prospect in the repair of fractures and bone defects by combining advanced material manufacturing technology and the excellent biological activity of manganese.