中青年发生缺血性脑卒中相关危险因素分析

Analysis of risk factors for ischemic stroke in young and middle-aged people

目的:探索中青年发生缺血性脑卒中的危险因素,为疾病预防提供干预依据。方法:选取2019年1月至2021年8月在沈阳医学院2所附属医院神经内科住院治疗的250例中青年缺血性脑卒中患者作为病例组,采用1∶1配比法选取在门诊参加健康体检的250例中青年为对照组。采用Logistic回归分析确定中青年发生缺血性脑卒中患者的危险因素。结果:高总胆固醇(OR=1.480,95%CI:1.035~2.117)、高甘油三酯(OR=1.304,95%CI:1.034~1.644)、高低密度脂蛋白胆固醇(OR=1.806,95%CI:1.227~2.656)、高空腹血糖(OR=1.215,95%CI:1.077~1.371)、高血清尿酸(OR=1.004,95%CI:1.001~1.007)、高血压病史(OR=24.422,95%CI:14.452~41.271)、吸烟史(OR=1.791,95%CI:1.074~2.986)、饮酒史(OR=2.292,95%CI:1.395~3.764)是中青年缺血性脑卒中发生的危险因素(P<0.05),高高密度脂蛋白胆固醇(OR=0.383,95%CI:0.169~0.866)是中青年缺血性脑卒中的保护因素(P<0.05)。结论:动脉粥样硬化是中青年发生缺血性脑卒中的重要危险因素,早期预防动脉粥样硬化、控制血糖、监控血压、健康生活方式对降低缺血性脑卒中的发生率有重要意义。

Objective:To explore the risk factors of ischemic stroke in young and middle-aged people,and to provide intervention basis for disease prevention.Methods:A total of 250 young and middle-aged patients with ischemic stroke who were hospitalized in the Department of Neurology of two affiliated hospitals of Shenyang Medical College from Jan 2019 to Aug 2021 were selected as the case group.The 1∶1 matching method was used.A total of 250 young and middle-aged people who participated in the health examination in the outpatient clinic were selected as the control group.Logistic regression analysis was used to determine the risk factors of ischemic stroke in young and middle-aged patients.Results:High total cholesterol(OR=1.480,95%CI:1.035-2.117),high triglyceride(OR=1.304,95%CI:1.034-1.644),high low-density lipoprotein cholesterol(OR=1.806,95%CI:1.227-2.656),high fasting blood glucose(OR=1.215,95%CI:1.077-1.371),high serum uric acid(OR=1.004,95%CI:1.001-1.007),hypertension(OR=24.422,95%CI:14.452-41.271),smoking(OR=1.791,95%CI:1.074-2.986),drinking(OR=2.292,95%CI:1.395-3.764)were risk factors for ischemic stroke in young and middle-aged people(P<0.05),and high high-density lipoprotein cholesterol(OR=0.383,95%CI:0.169-0.866)was a protective factor for ischemic stroke in young and middle-aged people(P<0.05).Conclusions:Atherosclerosis is an important risk factor for ischemic stroke in young and middle-aged people.Early prevention of atherosclerosis,control of blood glucose,monitoring of blood pressure and healthy lifestyle are of great significance to reduce the incidence of ischemic stroke.