Stratifin蛋白在肿瘤中的研究进展

Study progress in Stratifin protein in tumor

14-3-3蛋白是一种相对分子质量为(28~30)×103的酸性糖蛋白,在所有真核细胞中普遍表达且进化上相对保守。14-3-3蛋白家族由7种亚型(β、γ、ε、η、ζ、σ、τ/θ)组成,在调控细胞增殖、分化、衰老、凋亡、迁移、侵袭、细胞内信号转导、细胞周期进程、炎症等过程中发挥作用。Stratifin蛋白(14-3-3σ)是14-3-3蛋白家族中较为独特的一种亚型,它是一种同型二聚体蛋白,内含两亲性结合槽,可以与磷酸化的蛋白质氨基酸位点结合,从而调控蛋白质功能。该文就14-3-3σ状态的变化,对肿瘤的周期调控,在肿瘤发生、发展中细胞行为和代谢改变的调控,与结合蛋白的相互作用和未来临床治疗的研究方向进行综述。

The 14-3-3 protein is an acidic glycoprotein with a molecular weight of(28-30)×103,generally expressed in all eukaryotic cells and relatively conserved in evolution.The 14-3-3 protein family consists of seven subtypes(β,γ,ε,η,ζ,σ,τ/θ),and plays a role in the processes of regulating the cell proliferation,differentiation,senescence,apoptosis,migration,invasioin,intracellular signal transduction,cell cycle progression and inflammation.Stratifin protein(14-3-3σ)is a more unique subtype of the 14-3-3 protein family,it is a homodimer protein containing an amphiphilic bindinig groove that can bind to phosphorylated amino acid sites of the protein,thereby regulate the protein function.This paper reviews the 14-3-3σstatus change on cycle regulation of tumor,cellular behavior during the tumor occurrence and development,regulation of metoblic change,interaction with the binding protein and research directions of future clinical therapeutic.