摘要
miRNA几乎在所有的真核生物中均有表达,在许多生物学进程和疾病发展中扮演着不同的角色,最近它与放射性肺损伤(RILI)之间的联系也正逐渐被揭开。作为放疗最常见的并发症之一,RILI目前的治疗措施仍非常有限。本文对miRNA调节RILI的潜在机制进行综述,介绍了miRNA在基因组水平对RILI的保护,阐述了miRNA通过调节细胞因子的分泌和核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体的功能减轻放射性肺炎以及抑制转化生长因子-β(TGF-β)/Smad信号通路和上皮细胞-间充质转化延缓放射性肺纤维化的进程。
miRNA is expressed in almost all eukaryotes and plays different roles in many biological processes and disease development.Recently,the relationship between miRNA and radiation-induced lung injury(RILI)has been gradually revealed.As one of the most common complications of radiotherapy,RILI still has very limited treatment measures currently.In this paper,we review the potential mechanisms of miRNA in the regulation of RILI,introduce the protection of RILI by miRNA at the genomic level,and elaborate that miRNA reduces radiation pneumonitis and inhibits TGF-β/Smad signaling pathway and epithelial-mesenchymal transition to delay the process of radiation-induced pulmonary fibrosis by regulating cytokine secretion and the function of NLRP3 inflammasomes.
作者
李淑晶
张瑞新
李硕
宁方玲
LI Shujing;ZHANG Ruixin;LI Shuo;NING Fangling(Department of Oncology,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)
出处
《中国医药科学》
2023年第5期74-77,共4页
China Medicine And Pharmacy
基金
滨州医学院徐荣祥再生医学发展计划项目(BY2019XRX05)。
关键词
MIRNA
放射性肺损伤
肿瘤
炎症
纤维化
miRNA
Radiation-induced lung injury
Tumor
Inflammation
Fibrosis
