老年糖尿病患者血清C反应蛋白水平与抑郁事件相关性分析

Correlation analysis of serum C-reactive protein level and depressive events in elderly diabetic patients

目的探讨老年糖尿病患者血清C反应蛋白(CRP)水平与抑郁事件发生之间的关系。方法将收集的2016年1月至2019年9月在南阳市中心医院就诊的288例老年糖尿病患者设为研究组,同期在体检中心选取无糖尿病的健康老年人群作为对照组。收集两组人群的数据并分析血清CRP水平与糖尿病患者发生抑郁事件的相关性。结果多元回归分析显示,糖尿病患者血清CRP水平与抑郁评分呈正相关(回归系数=0.179,P<0.001),与年龄、性别、BMI、婚姻状况、受教育程度、吸烟状况、饮酒状况、锻炼活动、心血管疾病史、实验室检查等因素无关。但分层分析发现,服用抗抑郁药之后,血清CRP水平与抑郁评分相关性消失;随访3年后,糖尿病患者血清CRP水平与抑郁事件发生显著相关(P<0.05)。将上述混杂因素进行调整后研究发现,在老年糖尿病人群中,血清CRP水平升高与抑郁发生风险增加相关(OR=1.304,95%CI:1.014,1.861,P=0.011),但是在未患糖尿病的老年人群中,血清CRP水平升高与抑郁发生风险无关(OR=1.004,95%CI:0.992,1.013,P=0.341)。结论老年糖尿病患者血清CRP水平与抑郁事件发生之间存在显著的正相关。

Objective To investigate the correlation between serum C-reactive protein(CRP)level and depressive events in elderly diabetic patients.Methods From January 2016 to September 2019,288 elderly diabetic patients treated in Nanyang Central Hospital were selected as the research group,and the healthy elderly without diabetes who received physical examinations were selected as the control group.Clinical data were collected to analyze the correlation between CRP level and depressive events in both groups.Results Multiple regression analysis showed that serum CRP level in elderly diabetic patients was positively correlated with depression scores(regression coefficient=0.179,P<0.001),which was not correlated with age,gender,body mass index(BMI),marital status,education level,smoking status,drinking status,exercises,history of cardiovascular diseases,and laboratory testing data.However,stratified analysis found that after taking antidepressants,the correlation between serum CRP level and depression scores in elderly diabetic patients disappeared.After 3 years of follow-up,serum CRP level in elderly diabetic patients was still significantly correlated with depression events(P<0.05).After adjusting the above confounding factors,serum CRP level in elderly diabetic patients was positively correlated with the risk of depressive symptoms(OR=1.304,95%CI:1.014,1.861,P=0.011),which,was not correlated in the healthy elderly without diabetes(OR=1.004,95%CI:0.992,1.013,P=0.341).Conclusion After adjusting various lifestyle factors,there is a significant positive correlation between the serum CRP level and the prevalence of depression in elderly diabetic patients.