基于数据挖掘研究中药熏洗促进肛瘘术后愈合的用药规律

The medication rule of promoting wound healing after anal fistula surgery by TCM medicine fumigation and washing based on data mining

目的:运用数据挖掘的方法探索中药熏洗促进肛瘘术后愈合的用药规律。方法:在中国知网、中国学术期刊数据库、万方、维普等数据库中,搜索并收集近十年(2012年1月1日-2022年1月1日)中药熏洗促进肛瘘术后愈合的全部相关文献,摘录出所有中药熏洗处方的药物组成和剂量。应用Excel 2019、IBM SPSS Modeler18.0、IBM SPSS Statistics 26.0等软件整理处方,对其用药频次、中药性味归经进行分析,并进行聚类分析、用药关联规律分析。结果:筛选出符合要求的相关文献共101篇,涉及65个中药处方、98味中药,其中用药频次>15的中药有6味,分别是黄柏、苦参、五倍子、芒硝、蒲公英、大黄。其四气以寒为主,五味以苦味为主,辅以辛味、甘味,归肝经者居多。聚类分析结果可将药物分成5大类。药物关联结果显示以黄柏-蒲公英组合居多。结论:中药熏洗促进肛瘘术后创面愈合以清热解毒、凉血止血、活血止痛、燥湿消肿、敛疮生肌为基本治则,多使用黄柏等苦寒类药物。

Objective:To explore the medication rule of promoting wound healing after anal fistula surgery by TCM medicine fumigation and washing through data mining method.Methods:In databases such as CNKI,CSPD,Wanfang Data,and VIP,all the studies about promoting wound healing after anal fistula surgery by TCM medicine fumigation and washing in recent ten years(from January 1,2012 to January 1,2022)were searched and collected,and the medicine composition and dose of all the included TCM fumigation and washing prescriptions were extracted.Software such as Microsoft Office Excel 2019,IBM SPSS Modeler18.0,and IBM SPSS Statistics 26.0 was used to sort out the prescriptions,and the medication frequency,medicinal property,medicinal flavors,and meridian tropism was analyzed.And the clustering analysis and medication association rule analysis of the prescriptions were performed.Results:There were 101 studies met the requirements,including 65 TCM prescriptions and 98 TCM medicines.Among them,there were 6 TCM medicines with a medication frequency of more than 15 times,namely Huangbo(Phellodendri Chinensis Cortex),Kushen(Sophorae Flavescentis Radix),Wubeizi(Galla Chinensis),Mangxiao(Natrii Sulfas),Pugongying(Taraxaci Herba),and Dahuang(Rhei Radix et Rhizoma).Their medicinal properties were mainly cold.Their medicinal flavors were mainly bitter,supplemented by acrid and sweet.The meridian tropism was mainly liver meridian.The results of cluster analysis showed that all the included medicines could be divided into 5 categories.The result of medicine association rules showed that the combination of Huangbo-Pugongying was the most.Conclusion:TCM medicine fumigation and washing for promoting wound healing after anal fistula is based on the basic treatment principles of clearing heat and detoxifying,cooling blood and stopping bleeding,promoting blood circulation to relieve pain,removing dampness and reducing swelling,and astringing sores and promoting muscle growth.Most of the medicines used are bitter and cold medicines such as Huangbo.