基于数据挖掘分析名中医许建秦教授治疗瘿病的用药规律

An analysis of the medication rule of treating thyroid disease by Professor XU Jianqin

目的:分析许建秦教授诊治瘿病的特色用药规律,为瘿病新药研发提供参考。方法:收集2019年7月1日-2021年7月1日许建秦教授门诊中医诊断瘿病的医案,共纳入病例150个(甲状腺功能减退症56例,甲状腺功能亢进症20例,甲状腺结节54例,甲状腺炎20例),涉及药物372味。运用中医传承辅助平台管理系统(V2.5)进行数据录入、分析、统计,得出用药特点和组方规律。筛选、构建许建秦教授治疗瘿病中药数据库,并对数据进行用药频次统计、组方规律、归经分布、四气五味分析。结果:许建秦教授诊治瘿病最常用的药物是温性药,药物四气所占比例:温性药物约为40.94%(791/1932),寒性药物约为34.21%(661/1932),平性药物约为20.19%(390/1932),凉性药物约为3.93%(76/1932),热性药物约为0.73%(14/1932);最常使用药物的性味为苦、甘,药物五味所占比例:苦味药约为37.55%(1133/3017),甘味药约为29.70%(896/3017),辛味药约为27.08%(817/3017),酸味药约为3.61%(109/3017),咸味药约为1.36%(41/3017),涩味药约为0.70%(21/3017);药物归经主要归脾、肝经。结论:文章通过数据挖掘的方法总结了许建秦教授治疗瘿病的用药规律,为进一步的新药研发提供了数据支撑。

Objective:To analyze the medication rule of Professor XU Jianqin’s treatment on thyroid disease,and provide reference for the research.Methods:The medical cases of thyroid disease diagnosed by Professor XU Jianqin from July 1,2019 to July 1,2021 were collected.And 150 cases(56 cases of hypothyroidism,20 cases of hyperthyroidism,54 cases of thyroid nodules,20 cases of thyroiditis)were included,involving 372 drugs.The TCM inheritance auxiliary platform management system(V2.5)was used to input,analyze and calculate the data,and drug characteristics and prescription rules were obtaned.The database for the treatment in traditional Chinese medicine of Professor XU Jianqin was constructed,and the statistics of drug frequency,prescription rule,meridian distribution and analysis of four gases and five flavors were analyzed.Results:Professor XU Jianqin’s most commonly used drug four character is warm drugs.The proportion of drug four characters:warm drugs were about 40.94%(791/1932),iced drugs were 34.21%(661/1932),flat drugs were 20.19%(390/1932),cold drugs were about 3.93%(76/1932),and thermal drugs were about 0.73%(14/1932).The most commonly used drug tastes were bitter and sweet.The proportion of five-flavor drugs:the bitter taste medicine was about 37.55%(1133/3017),the sweet medicine was about 29.70%(896/3017),the spicy medicine was about 27.08%(817/3017),the acid medicine was about 3.61%(109/3017),the saline medicine was about 1.36%(41/3017),and the acerbity medicine was about 0.70%(21/3017).The most commonly used collateral channels were the spleen and liver meridians.Conclusion:The medication rule of Professor XU Jianqin in the treatment of thyroid disease is summarized to provide data support for further new drug research and development.