非酒精性脂肪性肝病与急性胆管炎严重程度的相关性研究进展

Progress in the Study of the Correlation Between Non-Alcoholic Fatty Liver Disease and the Severity of Acute Cholangitis

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)和急性胆管炎是世界范围内常见的疾病,发病率不断增加,导致多种并发症和危及生命的疾病发生,包括肝硬化、肝细胞癌等。近年的研究发现,NAFLD与急性胆管炎之间存在关联,其中一方可能会促进另一方的发生和发展。现对NAFLD与急性胆管炎的发生和发展、可能的危险因素及严重程度之间的相互关系和可能的联系进行综述,以便进一步探究NAFLD和急性胆管炎的发病机制,更好地预防和治疗NAFLD和急性胆管炎,以期通过实施生活方式改变、减肥和NAFLD靶向药物早期应用最大限度地减少NAFLD发病率和降低急性胆管炎的死亡率。希望通过此研究,为今后急性胆管炎严重程度分级提供临床流行病学依据,为今后早期干预NAFLD进程来改善急性胆管炎的发病程度及预后提供理论基础。以期将NAFLD作为急性胆管炎严重程度分级的独立危险因素,对于合并NAFLD的急性胆管炎患者进行早期干预及治疗,预防其重症化。

Non-alcoholic fatty liver disease(NAFLD)and acute cholangitis are common worldwide,with an increasing incidence leading to a variety of comorbidities and life-threatening diseases,including cirrhosis and hepatocellular carcinoma.Recent studies have identified an association between NAFLD and acute cholangitis,where one may contribute to the development and progression of the other.The interrelationships and possible associations between NAFLD and the development and progression of acute cholangitis,possible risk factors and severity are reviewed in order to further investigate the pathogenesis of NAFLD and acute cholangitis and to better prevent and treat NAFLD and acute cholangitis,with a view to minimising the incidence of NAFLD and reducing acute cholangitis by implementing lifestyle changes,weight loss and early application of NAFLD-targeted drugs The aim is to minimise the incidence of NAFLD and reduce the mortality rate of acute cholangitis through the implementation of lifestyle changes,weight loss and early application of NAFLD-targeted drugs,and to provide a theoretical basis for future early intervention in the NAFLD process to improve the morbidity and prognosis of acute cholangitis.