不同浓度臭氧注射联合射频消融术治疗腰椎间盘突出症的疗效研究

Study on the efficacy of different concentrations of ozone injection combined with radiofrequency ablation in the treatment of lumbar disc herniation

目的探讨不同浓度臭氧注射联合射频消融术治疗腰椎间盘突出症(LDH)的临床效果。方法将75例LDH患者随机分为A组、B组、C组,每组25例。3组患者均行臭氧注射联合射频消融术治疗,其中A组、B组、C组分别予40 mg/L、50 mg/L、60 mg/L医用臭氧注入病变椎间盘内。比较3组患者术前3 d、术后1 d、术后1个月、术后3个月、术后6个月的VAS评分和Oswestry功能障碍指数(ODI)评分。结果(1)术后各时间点,3组患者的VAS评分均较术前3 d低(均P<0.05)。术后1 d、术后1个月及术后6个月,B组和C组患者的VAS评分均低于A组,且C组术后1 d和术后1个月的VAS评分均低于B组(均P<0.05);而术后3个月及6个月,B组与C组的VAS评分差异均无统计学意义(均P>0.05)。(2)术后各时间点,3组患者的ODI评分均较术前3 d低(均P<0.05)。术后1 d及术后1个月,B组和C组患者的ODI评分均低于A组,且C组的ODI评分低于B组(均P<0.05);术后3个月,C组患者的ODI评分低于A组(P<0.05),而A组与C组、B组与C组的评分差异均无统计学意义(均P>0.05);术后6个月,3组患者的ODI评分差异无统计学意义(P>0.05)。结论臭氧注射联合射频消融术治疗LDH可减轻患者腰部疼痛,促进腰部功能恢复。相对于40 mg/L和50 mg/L臭氧注射联合射频消融术,60 mg/L臭氧注射联合射频消融术治疗LDH的疗效更佳。

Objective To investigate the clinical effect of different concentrations of ozone injection combined with radiofrequency ablation in the treatment of lumbar disc herniation(LDH).Methods A total of 75 LDH patients were randomly divided into group A,group B and group C,with 25 cases in each group.All patients in the three groups were treated with ozone injection combined with radiofrequency ablation,of which 40 mg/L,50 mg/L and 60 mg/L medical ozone were injected into the diseased intervertebral disc in groups A,B and C,respectively.The VAS scores and Oswestry disability index(ODI)scores of the three groups were compared 3 days before surgery,1 day after surgery,and 1,3 and 6 months after surgery.Results(1)At each time point after surgery,the VAS scores of the 3 groups were lower than those 3 days before surgery(all P<0.05).The VAS scores of group B and C were lower than those of group A 1 day,1 month and 6 months after surgery,and the VAS scores of group C 1 day and 1 month after surgery were lower than those of group B(all P<0.05).However,there was no significant difference in the VAS scores between group B and group C 3 or 6 months after surgery(all P>0.05).(2)At each time point after surgery,the ODI scores of the three groups were lower than those 3 days before surgery(all P<0.05).One day and 1 month after surgery,the ODI scores of group B and C were lower than that of group A,and the ODI score of group C was lower than that of group B(all P<0.05).Three months after surgery,the ODI score of group C was lower than that of group A(P<0.05),while there was no significant difference in the ODI scores between group A and group C,and between group B and group C(all P>0.05).Six months after surgery,there was no significant difference in the ODI scores among the three groups(P>0.05).Conclusion Ozone injection combined with radiofrequency ablation in the treatment of LDH can reduce lumbar pain and promote the recovery of lumbar function.Compared with 40 mg/L and 50 mg/L ozone injection combined with radiofrequency ablation,60 mg/L ozone injection combined with radiofrequency ablation is more effective in the treatment of LDH.