葡萄糖酸钙联合rhGH治疗少儿特发性矮小症的疗效

ffect of Calcium Gluconate Combined with rhGH in the Treatment of Children with Idiopathic Short Sta

目的:探讨葡萄糖酸钙联合重组人生长激素(rhGH)治疗少儿特发性矮小症的疗效。方法:选取2020年3月至2021年9月期间于商丘市第三人民医院诊治的80例特发性矮小症患儿,随机将其分为对照组40例,观察组40例。对照组患儿给予rhGH治疗,观察组患儿给予葡萄糖酸钙联合rhGH进行治疗,比较两组患儿治疗前后生长指标、骨代谢指标及治疗期间不良反应发生情况。结果:观察组患儿治疗12个月后身高高于对照组,生长速率快于对照组,骨龄大于对照组,差异均具有统计学意义(P<0.05);观察组患儿治疗12个月后血清骨特异性碱性磷酸酶(BAP)、骨钙素(OC)、Ⅰ型胶原交联羧基末端肽(ICTP)、Ⅰ型前胶原氨基端前肽(PINP)水平均显著高于对照组,差异具有统计学意义(P<0.05)。两组患儿治疗12个月期间均未发生严重不良反应。结论:在特发性矮小症患儿中给予葡萄糖酸钙联合rhGH治疗,可促进患儿生长,有效提高患儿骨龄,改善其骨代谢水平。

Objective To investigate the effect of calcium gluconate combined with recombinant human growth hormone(rhGH)in the treatment of children with idiopathic short stature.Methods A total of 80 children with idiopathic short stature diagnosed and treated in Shangqiu Third People's Hospital from March 2020 to September 2021 were selected and randomly divided into a control group and an observation group with 40 cases in each group.The control group was treated with rhGH,and the observation group was treated with calcium gluconate combined with rhGH.The growth indexes and bone metabolism indexes before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results After 12 months of treatment,the height of the observation group was higher than that of the control group,the growth rate was faster than that of the control group,and the bone age was higher than that of the control group,the differences were statistically significant(P<0.05).After 12 months of treatment,the serum levels of bone-specific alkaline phosphatases(BAP),osteocalcin(OC),type I collagen carboxy-terminal cross-linked peptide(ICTP)and N-terminal propeptide of typeⅠprocollagen(PINP)in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).No serious adverse reactions occurred in the two groups during 12 months of treatment.Conclusion Children with idiopathic short stature,calcium gluconate combined with rhGH treatment can promote the growth of the children,effectively improve the bone age,and improve the level of bone metabolism.