择时运动对代谢综合征的健康效应研究进展

Research Progress on the Health Effects of Chrono-Exercise on Metabolic Syndrome

通过系统检索PubMed、Web of Science、Embase、Scopus和中国知网等数据库中与择时运动、代谢综合征相关的文献,分析择时运动、昼夜节律与代谢综合征的关系。发现:一天中不同时间的运动会影响血糖代谢反应,择时运动对血糖代谢的影响与进餐时间有关;择时运动能够降低代谢与心血管风险,与早上运动相比,晚上运动对降低血压有更大益处;AMPK、PGC1α以及HIF1α在运动调节昼夜节律影响代谢性疾病中发挥重要作用,这可能是择时运动影响代谢健康的潜在机制。认为:择时运动可作为昼夜节律紊乱相关病理的有效处方,将择时运动和进餐时间与分子时钟同步会最大限度地发挥运动对全身代谢健康的促进作用。未来研究可尝试探索不同运动在一天中的不同时间对机体代谢的影响,以最大限度地提高运动效益。

A systematic review of relevant research in PubMed,Web of Science,Embase,Scopus and China National Knowledge Internet(CNKI)was conducted to review the literature related to chrono-exercise and metabolic syndrome,trying to analyze the relationship between chrono-exercise,circadian rhythm and metabolic syndrome.It is found that the effect of exercise at different times of the day on glucose metabolism was related to the timing of meals.Chrono-exercise reduced metabolic and cardiovascular risk,and evening exercise had a greater benefit on lowering blood pressure than morning exercise did.AMPK,PGC1α,and HIF1αcytokines played important roles in the regulation of circadian rhythms by exercise to affect metabolic diseases,which may be a potential mechanism for chrono-exercise to affect metabolic health.Conclusion was drawn that chrono-exercise could be an effective prescription for circadian rhythm disorder-related pathologies,and synchronizing chrono-exercise and meal timing with the molecular clock would also maximize the beneficial effects of exercise on systemic metabolic health.Future research should address the effects of different exercises at different times of the day on the metabolic health of the body to maximize the benefits of exercise.