麦角新碱注射液联合缩宫素预防宫缩乏力性产后出血的应用观察

Effect of Ergostine Injection Combined with Oxytocin on Preventing Postpartum Hemorrhage Caused by Uterine Fatigue

目的 观察麦角新碱注射液联合缩宫素预防宫缩乏力性产后出血(PPH)的应用效果。方法 采用随机数字表法将2019年4月至2021年4月于本院住院分娩的106例孕妇分为两组,每组各53例。对照组于胎儿娩出后予以缩宫素注射液,观察组于胎儿娩出后予以麦角新碱注射液联合缩宫素预防。比较两组PPH发生率、产后出血量、子宫复旧、血流动力学参数、凝血功能指标及不良反应。结果 观察组PPH发生率低于对照组,产后2、24 h出血量及产后3、5 d宫底高度低于对照组,有统计学差异(P<0.05)。两组产前、产后24 h心率、舒张压及收缩压比较,无统计学意义(P>0.05)。观察组分娩后凝血酶原时间、D-二聚体低于对照组,纤维蛋白原、血小板计数高于对照组,有统计学差异(P<0.05)。对照组、观察组不良反应发生率分别为5.66%、9.43%,无统计学差异(P>0.05)。结论 麦角新碱注射液联合缩宫素可有效预防PPH,发挥凝血机制,减少产后出血量,促进子宫复旧,安全性好,值得推广。

Objective To observe the effect of ergostine injection combined with oxytocin in the prevention of postpartum hemorrhage caused by uterine fatigue(PPH).Methods A total of 106 pregnant women who delivered in our hospital from April 2019 to April 2021 were divided into two groups by random number table method,with 53 cases in each group.The control group was given oxytocin injection after fetal delivery,while the observation group was given ergostine injection combined with oxytocin prophylaxis after fetal delivery.The incidence of PPH,postpartum blood loss,uterine involution,hemodynamic parameters,coagulation function indexes and adverse reactions were compared between the two groups.Results The incidence of PPH in the observation group was lower than that in the control group,and the blood loss at 2 and 24 hours after delivery and the fundus height at 3 and 5 days after delivery were lower than those in the control group,with statistical dif-ferences(P<C 0.05).There was no significant difference in heart rate,diastolic blood pressure and systolic blood pressure before and 24 hours after delivery between the two groups(P>0.05).The prothrombin time and Ddimer of the observation group after delivery were lower than those of the control group,and the fibrinogen and platelet counts were higher than those of the control group,with statistical differences(P<0.05).The incidence of adverse reactions in the control group and the observation group were 5.66%and 9.43%,respectively,with no statistical difference(P〉0.05).Conclusion Ergostine injection combined with oxytocin can effectively prevent PPH,play a role in coagulation mechanism,reduce postpartum blood loss,promote uterine involvement, with good safety, worthy of promotion.