甘精胰岛素联合琥珀酸美托洛尔治疗老年糖尿病伴高血压的效果分析

Effect Analysis of Insulin Glargine Combined with Metoprolol Succinate in Treatment of Elderly Patients with Diabe⁃tes Mellitus and Hypertension

目的:探讨甘精胰岛素与琥珀酸美托洛尔联合治疗糖尿病伴高血压老年患者的效果。方法:选取2019年11月—2021年11月在北京市房山区长阳镇社区卫生服务中心接受治疗的100例糖尿病伴有高血压老年患者作为研究对象,采用编号法分为观察组与对照组,各50例。对照组给予甘精胰岛素治疗,观察组在对照组基础上加用琥珀酸美托洛尔治疗。比较两组肾功能指标、血糖、血压、不良反应发生情况。结果:治疗前,两组血清尿素氮(BUN)、血清肌酐(Scr)、尿酸(UA)水平比较,差异无统计学意义(P>0.05);治疗后,两组BUN、Scr、UA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组空腹血糖、餐后2 h血糖水平比较,差异无统计学意义(P>0.05);治疗后,两组空腹血糖,餐后2 h血糖水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组收缩压、舒张压比较差异无统计学意义(P>0.05);治疗后,两组收缩压、舒张压均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:甘精胰岛素与琥珀酸美托洛尔联合治疗糖尿病伴高血压老年患者具有显著的临床效果,能够改善老年患者的肾功能,控制血糖,维持血压情况,并且安全性较高。

Objective:To investigate the effect of insulin glargine combined with metoprolol succinate in the treatment of elderly patients with diabetes mellitus and hypertension.Methods:A total of 100 elderly patients with diabetes mellitus and hypertension treated in Changyang Town Community Health Service Center of Fangshan District in Beijing from November 2019 to November 2021 were selected as research subjects.They were divided into observation group and control group by numbering method,with 50 cases in each group.Insulin glargine treatment was conducted in the control group.Metoprolol succinate treatment on the basis of control group was conducted in the observation group.Renal function indicators,blood glucose,blood pressure,and adverse reactions were compared between the two groups.Results:Before treatment,there was no statistically significant difference in the levels of serum urea nitrogen(BUN),serum creatinine(Scr),and uric acid(UA)between the two groups(P>0.05).After treatment,the levels of BUN,Scr,and UA in both groups were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in fasting blood glucose and 2 h postprandial blood glucose levels between the two groups(P>0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose levels in the two groups were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).After treatment,systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Insulin glargine combined with metoprolol succinate has a very significant clinical effect on elderly patients with diabetes mellitus and hypertension.It can improve the renal function of elderly patients,control their blood glucose and maintain their blood pressure,with high safety.