阿莫西林克拉维酸钾联合阿奇霉素治疗小儿社区获得性肺炎的效果分析

Effect Analysis of Amoxicillin and Clavulanate Potassium Combined with Azithromycin in Treatment of Community-Acquired Pneumonia in Children

目的:探讨阿莫西林克拉维酸钾联合阿奇霉素治疗小儿社区获得性肺炎的效果。方法:选取2021年6月—2022年6月朝阳区豆各庄社区卫生服务中心收治的74例社区获得性肺炎患儿作为研究对象,根据随机数字表法分为对照组与观察组,各37例。对照组给予阿莫西林克拉维酸钾治疗,观察组在对照组基础上给予阿奇霉素治疗,比较两组治疗效果、临床症状缓解时间及住院时间、血清炎性因子水平、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组发热、咳嗽、气喘缓解时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、血清肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、CRP、TNF-α水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿莫西林克拉维酸钾联合阿奇霉素治疗小儿社区获得性肺炎的效果显著,可减轻炎性反应,促进患儿临床症状改善,缩短患儿康复时间。

Objective:To investigate the effect of amoxicillin and clavulanate potassium combined with azithromycin in the treat⁃ment of community-acquired pneumonia in children.Methods:A total of 74 children with community-acquired pneumonia admit⁃ted to Dougezhuang Community Health Service Center in Chaoyang District from June 2021 to June 2022 were selected as the study subjects,and they were divided into control group and observation group according to the random number table method,with 37 children in each group.The control group was treated with amoxicillin and clavulanate potassium,and the observation group was treated with azithromycin on the basis of the control group.The treatment effect,clinical symptom relief time and hospital stay,serum inflammatory factor level,and occurrence of adverse reactions were compared between the two groups.Results:The to⁃tal effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The fever,cough,asthma relief time and hospital stay in observation group were shorter than those in control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of interleukin-6(IL-6),C-reactive protein(CRP),and serum tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After treatment,the levels of IL-6,CRP and TNF-αin the two groups were lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).There was no significant differ⁃ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Amoxicillin and clavulanate potassium combined with azithromycin in the treatment of community-acquired pneumonia in children has a significant effect,which can re⁃duce inflammation reaction,promote the improvement of clinical symptoms and shorten the recovery time of children.