基于功能磁共振成像探讨针灸治疗肠易激综合征患者脑功能改变的研究进展

Research progress on brain functional alterations in patients with irritable bowel syndrome treated by acupuncture-moxibustion based on functional magnetic resonance imaging

肠易激综合征(IBS)是一种慢性功能性胃肠病,虽然不会危及患者生命,但影响其生活质量,并增加抑郁症等精神疾病的发生风险。鉴于此,有必要对IBS的中枢发病机制进行探讨。功能磁共振成像是研究脑功能的一种非常有效、非侵入性活体观测技术,为评估IBS的“脑-肠轴”异常提供了新的视角。针灸治疗IBS效果肯定,但其中枢机制不完全清楚。本文对近几年国内外针灸相关文献进行回顾,并对几种功能磁共振成像研究方法在IBS中的应用进行综述。

Irritable bowel syndrome(IBS)is a chronic functional gastrointestinal disease.It is not life-threatening,but affects the quality of life and increases the risk of psychiatric disorders such as depression.Therefore,it is necessary to explore the brain central pathogenesis of IBS.Functional magnetic resonance imaging is a very effective and non-invasive in vivo observation technique for studying brain function,which provides a new perspective for evaluating the abnormality of“brain-gut axis”in IBS.Although the efficacy of acupuncture-moxibustion on IBS are positive,their brain central mechanisms are still unclear.This article reviews relevant domestic and foreign literature of acupuncture-moxibustion in recent years,and summarizes the application of functional magnetic resonance imaging technology in IBS.