活血化瘀类中药抗炎机制研究进展

Research progress on anti-inflammatory mechanism of blood-activating and stasis-resolving traditional Chinese medicine

活血化瘀类中药主要用于内科诸痛、经闭痛经、跌打损伤、疮疡肿痛等血瘀证,炎症是机体对各种损伤刺激做出的自然应答,活血化瘀类中药在抑制炎症反应方面具有一定优势。本文通过检索文献,对延胡索、川芎、丹参、郁金、乳香、益母草、牛膝、马钱子、水蛭9味中药的抗炎机制进行分析,发现活血化瘀类中药主要通过核因子-κB、丝裂原激活蛋白激酶、核转录因子E2相关因子2-抗氧化反应元件3条信号通路发挥抗炎作用,并针对该研究领域存在的问题提供研究方向,为今后进一步探索活血化瘀类中药的抗炎成分靶点及临床应用提供可靠的理论依据。

Blood-activating and stasis-resolving traditional Chinese medicines are mainly used for blood stasis syndrome of the pain of internal medicine,amenorrhoea,dysmenorrhea,traumatic injury,sore and ulcer,swelling,and so on.Inflammation is the natural response of the body to various injury stimuli.Blood-activating and stasis-resolving traditional Chinese medicine has certain advantages in inhibiting inflammatory reaction.This paper analyzes the anti-inflammatory mechanism of nine traditional Chinese medicines including Corydalis Rhizoma,Chuanxiong Rhizoma,Salviae Miltiorrhizae Radix Et Rhizoma,Curcumae Radix,Olibanum,Leonuri Herba,Achyranthis Bidentatae Radix,Strychni Semen,and Hirudo by searching the literature.It is found that blood-activating and stasis-resolving traditional Chinese medicine mainly plays an anti-inflammatory role by three signal pathways of nuclear factor-κB,mitogen-activated protein kinase,nuclear transcription factor E2 related factor 2-antioxidant response element.It also provides research direction for the existing problems in this research field,and provides reliable theoretical basis for further exploring the anti-inflammatory component target and clinical application of blood-activating and stasis-resolving traditional Chinese medicines.