无创通气联合二羟丙茶碱治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床疗效分析

Clinical Analysis of Non-invasive Ventilation Combined with Dihydroxypropyl Theophylline in the Treatment of Chronic Obstructive Pulmonary Disease with TypeⅡRespiratory Failure

目的 探讨对慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭者予无创通气联合二羟丙茶碱治疗的临床效果。方法 选取2019年1月—2022年1月扬州市江都人民医院收治的慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的患者120例为研究对象,以随机数表法将患者分为对照组(行常规治疗)和观察组(采用无创通气联合二羟丙茶碱治疗),每组60例。对比两组临床疗效、治疗前后血气指标、治疗前后症状评分与耐力水平、不良反应发生率。结果 观察组总有效率较对照组高(95.00%vs 83.33%),差异有统计学意义(χ^(2)=4.227,P<0.05)。观察组治疗后氧分压(83.12±6.46)mmHg、血氧饱和度(96.45±3.01)%高于对照组;二氧化碳分压(35.68±4.10)mmHg低于对照组,差异有统计学意义(t=8.038、6.514、6.424,P<0.05)。观察组治疗后CAT评分(16.52±3.12)分低于对照组;6 MWT(383.25±36.73)m优于对照组,差异有统计学意义(t=5.408、9.154,P<0.05)。两组不良反应率发生率对比,差异无统计学意义(P>0.05)。结论 对慢阻肺合并Ⅱ型呼吸衰竭患者采用无创通气联合二羟丙茶碱治疗的疗效可靠,能改善患者血气指标,减轻患者症状并提高运动耐力。

Objective To explore the clinical effect of non-invasive ventilation combined with dihydroxypropyl theophylline on patients with chronic obstructive pulmonary disease(COPD)complicated with typeⅡrespiratory failure.Methods 120 patients with chronic obstructive pulmonary disease and typeⅡrespiratory failure admitted to Jiangdu People´s Hospital of Yangzhou City from January 2019 to January 2022 were selected as the study subjects.The patients were divided into control group(routine treatment)and observation group(non-invasive ventilation combined with dihydroxytheophylline treatment)by random number table method,with 60 patients in each group.The clinical efficacy,blood gas index,symptom score and endurance level before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(95.00%vs 83.33%),and the difference was statistically significant(χ^(2)=4.227,P<0.05).After treatment,the oxygen partial pressure(83.12±6.46)mmHg and blood oxygen saturation(96.45±3.01)%in the observation group were higher than those in the control group;the partial pressure of carbon dioxide(35.68±4.10)mmHg was significantly lower than that of the control group,the difference was statistically significant(t=8.038,6.514,6.424,P<0.05).The CAT score(16.52±3.12)points of the observation group after treatment was lower than that of the control group;6 MWT(383.25± 36.73) m was better than the control group, the difference was statistically significant (t=5.408, 9.154, P<0.05). There was no statistically significantdifference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Non-invasive ventilation combined withdihydroxypropyl theophylline has a reliable therapeutic effect on patients with chronic obstructive pulmonary disease (COPD) complicatedwith type Ⅱ respiratory failure. It can improve the blood gas index of patients, alleviate the symptoms of patients and improve exercise endurance.