甲状腺射频消融术治疗甲状腺结节患者的效果

Effects of thyroid radiofrequency ablation on patients with thyroid nodules

目的:观察甲状腺射频消融术治疗甲状腺结节患者的效果。方法:选取2019年1—12月该院收治的80例甲状腺结节患者进行前瞻性研究,以随机数字表法将其分为对照组和观察组各40例。对照组实施传统甲状腺切除术治疗,观察组实施甲状腺射频消融术治疗,比较两组临床疗效、围术期指标水平、手术前后血清氧化应激指标[丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)]水平和甲状腺功能指标[血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]水平。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);观察组手术时长、住院时长均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);术后,两组MDA水平均高于术前,但观察组低于对照组,两组SOD、GSH-Px和CAT水平均低于术前,但观察组高于对照组,差异有统计学意义(P<0.05);术后,两组TSH水平均低于术前,且观察组低于对照组,两组FT_(3)和FT_(4)水平均高于术前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:甲状腺射频消融术治疗甲状腺结节患者可提高治疗总有效率,改善血清氧化应激指标和甲状腺功能指标水平,降低围术期指标水平,效果优于传统甲状腺切除术治疗。

Objective:To observe effects of thyroid radiofrequency ablation on patients with thyroid nodules.Methods:A prospective study was conducted on 80 patients with thyroid nodules admitted to the hospital from January to December 2019.They were divided into control group and observation group by using the random number table method,40 patients in each group.The control group was treated with traditional thyroidectomy,while the observation group was treated with thyroid radiofrequency ablation.The clinical efficacy,the perioperative index levels,the serum oxidative stress index levels[malondialdehyde(MDA),catalase(CAT),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]level,and the thyroid function index levels[serum thyrotropin(TSH),free triiodothyronine(FT_(3)),free thyroxine(FT_(4))]before and after the surgery were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.00%(38/40),which was higher than 80.00%(32/40)in the control group,and the difference was statistically significant(P<0.05).The operation time and the hospitalization time in the observation group were shorter than those in the control group,the amount of intraoperative bleeding was less than that in the control group,and the differences were statistically significant(P<0.05).After the surgery,the levels of MDA in both groups were higher than those before the surgery,but the level of MDA in the observation group was lower than that in the control group;the levels of SOD,GSH-Px and CAT in the two groups were lower than those before the surgery,but those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the surgery,the TSH levels in both groups were lower than those before the surgery,and that in the observation group was lower than that in the control group;the levels of FT_(3)and FT_(4)in the two groups were higher than those before the surgery,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Thyroid radiofrequency ablation of thyroid nodules can improve the total effective rate of treatment,improve the levels of serum oxidative stress indexes and thyroid function indexes,and reduce the levels of perioperative indexes.Moreover,it is superior to traditional thyroidectomy.