血府逐瘀汤联合苯磺酸氨氯地平治疗瘀血阻络型老年高血压患者的效果

Effects of Xuefu Zhuyu decoction combined with Amlodipine besylate in treatment of elderly patients with hypertension of blood stasis type

目的:观察血府逐瘀汤联合苯磺酸氨氯地平治疗瘀血阻络型老年高血压患者的效果。方法:选取2019年4月至2021年10月该院收治的82例瘀血阻络型老年高血压患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各41例,对照组采用苯磺酸氨氯地平片治疗,观察组在对照组基础上联合血府逐瘀汤治疗,比较两组治疗前后血压[舒张压(DBP)、收缩压(SBP)]水平、动态血压指标[24 h平均收缩压(24hSBP)、日平均收缩压(dSBP)、夜平均收缩压(nSBP)、血压负荷]水平、血管内皮功能指标[一氧化氮(NO)、血栓素B2(TXB2)、内皮素-1(ET-1)水平、6-酮-前列素F-1α(6-Keto-PGF-1α)]水平、临床疗效和不良反应发生率。结果:治疗后,两组DBP、SBP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组24hSBP、dSBP、nSBP、血压负荷水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组NO和6-Keto-PGF-1α水平均高于治疗前,且观察组高于对照组,两组TXB2、ET-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.12%(39/41),高于对照组的80.49%(33/41),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异有统计学意义(P>0.05)。结论:血府逐瘀汤联合氨氯地平治疗瘀血阻络型老年高血压患者可降低血压水平和波动幅度,改善血管内皮功能指标水平,提高治疗总有效率,其效果优于单纯氨氯地平治疗。

Objective:To observe effects of Xuefu Zhuyu decoction combined with Amlodipine besylate in treatment of elderly patients with hypertension of blood stasis type.Methods:A prospective study was conducted on 82 elderly patients with hypertension of blood stasis type admitted to this hospital from April 2019 to October 2021.They were divided into control group and observation group according to the random number table method,41 cases in each.The control group was treated with Amlodipine besylate tablets,while the observation group was treated with Xuefu Zhuyu decoction on the basis of that of the control group.The levels of blood pressure[diastolic blood pressure(DBP),systolic blood pressure(SBP)],the ambulatory blood pressure index levels[24h mean systolic blood pressure(24h SBP),daily mean systolic blood pressure(dSBP),night mean systolic blood pressure(nSBP),blood pressure load],the vascular endothelial function index levels[nitric oxide(NO),thromboxane B2(TXB2),endothelin-1(ET-1),6-keto-prostaglandin F-1α(6-Keto-PGF-1α)],the clinical efficacy,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of DBP and SBP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of 24 hSBP,dSBP,nSBP and blood pressure load in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of NO and 6-Keto-PGF-1αin the two groups were higher than those before the treatment,and those in observation group were higher than those in the control group;the levels of TXB2 and ET-1 in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.12%(39/41),which was higher than 80.49%(33/41)in the control group,and the difference was statistically significant(P<0.05).Further,there was significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xuefu Zhuyu decoction combined with Amlodipine in the treatment of the elderly patients with hypertension of blood stasis type can reduce the blood pressure levels and the ambulatory blood pressure index levels,improve the vascular endothelial function index levels,and improve the 6-keto-prostaglandin F-1αlevel and total effective rate of treatment.Moreover,it is superior to single Amlodipine treatment.