参芪扶正注射液联合尼莫地平治疗脑梗死恢复期患者的效果

Effects of Shenqi Fuzheng injection combined with Nimodipine in treatment of patients with cerebral infarction in recovery period

目的:观察参芪扶正注射液联合尼莫地平治疗脑梗死恢复期患者的效果。方法:选取2020年2月至2022年2月该院收治的83例脑梗死恢复期患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=41)和观察组(n=42)。对照组给予尼莫地平治疗,观察组在对照组基础上联合参芪扶正注射液治疗,比较两组治疗前后神经认知功能[美国国立卫生研究院卒中量表(NIHSS)、简易智能精神状态量表(MMSE)]评分、血液流变学指标水平、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平及不良反应发生率。结果:治疗后,观察组MMSE评分高于对照组,NIHSS评分低于对照组,差异均有统计学意义(P<0.05);观察组全血高切黏度、全血低切黏度及血浆黏度等血液流变学指标水平低于对照组,差异均有统计学意义(P<0.05);观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参芪扶正注射液联合尼莫地平治疗脑梗死恢复期患者,可提高其神经功能和认知功能,改善血液黏度,增强免疫功能,效果优于单纯尼莫地平治疗。

Objective:To observe effects of Shenqi Fuzheng injection combined with Nimodipine in treatment of patients with cerebral infarction in recovery period.Methods:A prospective study was conducted on 83 with cerebral infarction in recovery period admitted to this hospital from February 2020 to February 2022.They were divided into control group(n=41)and observation group(n=42)according to the random number table method.The control group was treated with Nimodipine,while the observation group was treated with Shenqi Fuzheng injection on the basis of that of the control group.After the treatment,the scores of neurocognitive function[National Institutes of Health stroke scale(NIHSS),mini mental state examination(MMSE)],the hemorheology index levels,the T cell subsets index levels(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the MMSE score of the observation group was higher than that of the control group,the NIHSS score was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of hemorheology indexes such as whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Shenqi Fuzheng injection combined with Nimodipine in the treatment of the patients with cerebral infarction in recovery period can improve their neurological function and cognitive function,improve the blood viscosity and enhance the immune function.Moreover,it is superior to single Nimodipine treatment.