1例盐酸曲美他嗪片致合并肾功能不全老年患者帕金森综合征的药学监护

Pharmaceutical care for a case of Parkinson’s syndrome caused by trimetazidine hydrochloride tablets in an elderly patient with renal insufficiency

目的探讨肾功能不全老年患者使用盐酸曲美他嗪片致帕金森综合征的原因和机制,为临床合理使用盐酸曲美他嗪片提供参考。方法分析1例患者接受盐酸曲美他嗪片治疗后的诊疗过程,并进行相关文献回顾。结果患者接受盐酸曲美他嗪片治疗后第2天出现帕金森综合征,予以停用盐酸曲美他嗪片后患者帕金森综合征消失。结论盐酸曲美他嗪片致肾功能不全老年患者帕金森综合征风险高,治疗中应加强监护。

Objective To investigate the causes and mechanisms of parkinsonism induced by trimetazidine hydrochloride tablets in elderly patients with renal insufficiency,and to provide reference for rational clinical use of trimetazidine hydrochloride tablets.Methods The course of treatment of one patient after taking trimetazidine hydrochloride tablets was analyzed while related literature was reviewed.Results Parkinsonism occurred one day after treatment with trimetazidine hydrochloride tablets,but disappeared when these tablets were discontinued.Conclusion Trimetazidine hydrochloride tablets may increase the risk of parkinsonism in elderly patients with renal insufficiency and should be monitored during clinical use.