CD147和基质金属蛋白酶2在肝细胞癌中的表达及临床意义

The Expression and Clinical Signifcance of CD147 and MMP2 in Hepatocellular Carcinoma

目的:探讨肝细胞肝癌(HCC)组织中细胞外基质金属蛋白酶诱导因子(CD147)和基质金属蛋白酶2(MMP2)的表达情况及其意义。方法:运用免疫组化方法检测272例HCC中CD147的表达及282例HCC中MMP2的表达情况,并分析其与临床病理的关系。结果:272例HCC中,CD147的阳性表达与组织分级等不良预后指标相关(P<0.05);282例HCC中,MMP2的阳性表达与组织分级等不良预后指标相关(P<0.05)。生存分析显示,CD147和MMP2在HCC中阳性表达患者的生存时间均明显缩短,差异具有统计学意义(P<0.05)。CD47和MMP2在HCC中的表达无显著相关性(r=-0.079,P=0.124)。结论:CD147和MMP2在HCC中的阳性表达提示患者预后不良。

Objective To investigate the positive expression of CD147 and MMP2 and their clinical significance in hepatocellular carcinoma(HCC).Methods The positive expression of CD147 in 272 cases and MMP2 in 282 cases were tested with immunohistochemistry(IHC).Results(1)The positive expression of CD147 in 272 cases with HCC was closely correlated to some poor prognosis maker,such as the histological classification(P<0.05).The positive of MMP2 in 282 cases with HCC was closely related to some poor prognosis maker,such as the histological classification(P<0.05).(2)Survival analysis indicates that the positive of CD147 and MMP2 in HCC were significantly related to short-term survival(P<0.05).(3)Statistical analysis indicate that the expression of CD147 has no correlation with the expression of MMP2 in HCC(r=-0.079,P=0.124).Conclusion The patients of HCC with positive expression of CD147 and MMP2 has poor prognosis.