替普瑞酮结合奥美拉唑治疗重度糜烂性胃炎并发消化不良患者的效果及对其肠胃功能的影响

Effect of teprenone combined with omeprazole in the treatment of patients with severe erosive gastritis and dyspepsia and its influence on their gastrointestinal function

目的分析替普瑞酮胶囊结合奥美拉唑肠溶胶囊治疗重度糜烂性胃炎并发消化不良患者的效果及对其肠胃功能的影响。方法74例重度糜烂性胃炎并发消化不良患者,以随机数字表法分为观察组与对照组,每组37例。对照组应用奥美拉唑肠溶胶囊治疗,观察组在对照组基础上加用替普瑞酮胶囊治疗。比较两组治疗效果、不良反应发生情况、胃肠功能恢复情况及治疗前后视觉模拟评分法(VAS)评分。结果观察组治疗总有效率为91.89%,高于对照组的70.27%,差异有统计学意义(P<0.05)。观察组肠胃鸣时间(3.88±0.89)d、肛门排气时间(4.26±0.87)d、腹痛腹胀消除时间(4.09±0.65)d均短于对照组的(6.21±1.20)、(6.68±1.10)、(6.17±1.21)d,差异有统计学意义(P<0.05)。治疗后,观察组VAS评分为(2.20±1.27)分,明显低于对照组的(4.46±1.39)分,差异有统计学意义(P<0.05)。观察组不良反应发生率为8.11%,与对照组的10.81%比较,差异无统计学意义(P>0.05)。结论对重度糜烂性胃炎并发消化不良患者应用替普瑞酮胶囊联合奥美拉唑肠溶胶囊治疗可显著改善其病情,且治疗安全性较高。

Objective To analyze the effect of teprenone combined with omeprazole in the treatment of patients with severe erosive gastritis and dyspepsia and its influence on their gastrointestinal function.Methods A total of 74 patients with severe erosive gastritis and dyspepsia were divided into observation group and control group according to the random numerical table,with 37 cases in each group.The control group was treated with omeprazole enteric-coated capsules,and the observation group was treated with teprenone capsules on the basis of the control group.The therapeutic effect,occurrence of adverse reactions,recovery of gastrointestinal function,and the degree of pain visual analogue scale(VAS)score before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 91.89%,which was higher than 70.27%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the recovery time of bowel sounds was(3.88±0.89)d,the time of anal discharge was(4.26±0.87)d,and the disappearance time of abdominal pain and distension was(4.09±0.65)d,which were shorter than(6.21±1.20),(6.68±1.10),and(6.17±1.21)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the VAS score of the observation group was(2.20±1.27)points,which was significantly lower than(4.46±1.39)points of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 8.11%,and the difference was not statistically significant when compared with 10.81%in the control group(P>0.05).Conclusion Teprenone capsule combined with omeprazole enteric-coated capsules for patients with severe erosive gastritis complicated by dyspepsia can significantly improve their conditions and has a higher treatment safety.