摘要
目的探讨齐拉西酮联合氟西汀治疗精神分裂症阴性症状患者的临床疗效。方法102例精神分裂症阴性症状患者,随机分为对照组(50例)和研究组(52例)。对照组采用单一齐拉西酮治疗,研究组在对照组基础上联合氟西汀治疗。比较两组患者阳性和阴性症状量表(PANSS)评分、90项症状自评量表(SCL-90)评分、治疗效果及不良反应发生率。结果治疗后,研究组患者阳性症状、阴性症状及精神症状评分分别为(13.52±2.13)、(10.53±2.53)、(21.82±3.52)分,均低于对照组的(15.08±2.38)、(12.42±2.67)、(25.88±4.92)分,差异有统计学意义(P<0.05)。研究组患者躯体化、躯体强迫、人际关系、焦虑、抑郁、恐惧、偏执、敌对、精神病评分分别为(1.43±0.47)、(2.05±0.73)、(1.73±0.41)、(1.44±0.72)、(1.54±0.65)、(1.33±0.61)、(1.28±0.64)、(1.52±0.55)、(1.44±0.42)分,均低于对照组的(1.79±0.57)、(2.45±0.81)、(2.29±0.44)、(2.33±0.81)、(2.27±0.76)、(2.24±0.63)、(1.87±0.85)、(1.89±0.83)、(1.78±0.75)分,差异有统计学意义(P<0.05)。研究组患者治疗总有效率94.2%明显高于对照组的80.0%,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论对精神分裂症阴性症状患者采用齐拉西酮联合氟西汀治疗具有显著的效果,可改善其阴性症状,缓解不良情绪,且不增加不良反应,建议广泛应用。
Objective To discuss the clinical efficacy of ziprasidone combined with fluoxetine in the treatment of negative symptoms of schizophrenia.Methods A total of 102 patients with negative symptoms of schizophrenia were randomly divided into a control group(50 patients)and a research group(52 patients).The control group was treated with ziprasidone alone,and the research group was treated with fluoxetine on the basis of the control group.Both groups were compared in terms of positive and negative symptom scale(PANSS)scores,symptom check-list 90(SCL-90)scores,therapeutic effects,and incidence of adverse reactions.Results After treatment,the positive symptom,negative symptom and psychiatric symptom scores in the research group were(13.52±2.13),(10.53±2.53)and(21.82±3.52)points,which were lower than(15.08±2.38),(12.42±2.67)and(25.88±4.92)points in the control group,and the differences were statistically significant(P<0.05).The somatization,somatic compulsion,interpersonal,anxiety,depression,fear,paranoia,hostility,and psychosis scores in the research group were(1.43±0.47),(2.05±0.73),(1.73±0.41),(1.44±0.72),(1.54±0.65),(1.33±0.61),(1.28±0.64),(1.52±0.55),and(1.44±0.42)points,which were lower than(1.79±0.57),(2.45±0.81),(2.29±0.44),(2.33±0.81),(2.27±0.76),(2.24±0.63),(1.87±0.85),(1.89±0.83),and(1.78±0.75)points in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the research group was 94.2%,which was significantly higher than 80.0%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ziprasidone in combination with fluoxetine for the treatment of patients with negative symptoms of schizophrenia has a significant effect in improving their negative symptoms and relieving negative emotions without increasing adverse reactions,and is recommended for wide application.
作者
田颖
TIAN Ying(Dalian Civil Affairs Service Center(Dalian Social Welfare Institute),Dalian 116013,China)
出处
《中国现代药物应用》
2023年第5期146-149,共4页
Chinese Journal of Modern Drug Application