降浊清热饮联合来氟米特对肾小球肾炎患者的临床效果及药理分析

Clinical effect and pharmacological analysis of Jiangzhuo Qingre decoction combined with leflunomide on patients with glomerulonephritis

目的分析降浊清热饮联合来氟米特对肾小球肾炎患者的临床效果及其药理学机制。方法60例肾小球肾炎患者,根据治疗方案的差异分为试验组和对照组,每组30例。对照组患者应用来氟米特治疗,试验组在对照组基础上联合降浊清热饮内服方案治疗。比较两组患者治疗前后的中医证候评分、24 h尿蛋白定量以及临床疗效。结果治疗前,试验组中医证候评分为(17.45±2.36)分,24 h尿蛋白定量为(1.12±0.33)g/24 h;对照组中医证候评分为(17.44±2.28)分,24 h尿蛋白定量为(1.13±0.35)g/24 h。治疗后,试验组中医证候评分为(6.44±2.06)分,24 h尿蛋白定量为(0.38±0.15)g/24 h;对照组中医证候评分为(11.53±3.16)分,24 h尿蛋白定量为(0.67±0.21)g/24 h。治疗前,两组患者中医证候评分、24 h尿蛋白定量比较,差异均无统计学意义(P>0.05);治疗后,试验组患者中医证候评分、24 h尿蛋白定量低于对照组,差异均具有统计学意义(P<0.05)。试验组治疗总有效率90.00%高于对照组的66.67%,差异具有统计学意义(P<0.05)。结论降浊清热饮联合来氟米特治疗方案可有效抑制肾小球肾炎炎性损害进展,提高对肾脏代谢产物的滤过能力,清热通淋、益气降浊,临床效果显著,值得临床推广。

Objective To analyze the clinical effect and pharmacological mechanism of Jiangzhuo Qingre decoction combined with leflunomide on patients with glomerulonephritis.Methods A total of 60 patients with glomerulonephritis were divided into an experimental group and a control group according to the difference in treatment regimens,with 30 patients in each group.Patients in the control group were treated with leflunomide,and patients in the experimental group were treated with Jiangzhuo Qingre decoction on the basis of the control group.The traditional Chinese medicine syndrome score,24-h urinary protein quantification before and after treatment,and clinical efficacy of the two groups were compared.Results Before treatment,the traditional Chinese medicine syndrome score and 24-h urinary protein quantification were(17.45±2.36)points and(1.12±0.33)g/24 h in the experimental group,and(17.44±2.28)points and(1.13±0.35)g/24 h in the control group.After treatment,the traditional Chinese medicine syndrome score and 24-h urinary protein quantification were(6.44±2.06)points and(0.38±0.15)g/24 h,which were(11.53±3.16)points and(0.67±0.21)g/24 h in the control group.Before treatment,there was no statistically significant difference in the traditional Chinese medicine syndrome scores and 24-h urinary protein quantification between the two groups(P>0.05).After treatment,the traditional Chinese medicine syndrome scores and 24-h urinary protein quantification in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the experimental group was 90.00%,which was higher than 66.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of leflunomide and Jiangzhuo Qingre decoction has significant clinical effects on patients with glomerulonephritis,and can effectively inhibit the progression of inflammatory damage of glomerulonephritis,improve the filtration capacity of renal metabolites,clear heat and free strangury,benefit Qi and lower turbidity,which is worthy of clinical promotion.