奥氮平联合碳酸锂治疗双相情感障碍的效果研究

Study on Effect of Olanzapine Combined with Lithium Carbonate in Treatment of Bipolar Disorder

目的:探讨奥氮平联合碳酸锂治疗双相情感障碍的效果。方法:选取我院精神科2019年1月—2021年1月收治的60例双相情感障碍患者作为研究对象,依据随机数字表法分为对照组(30例)和观察组(30例)。对照组采用碳酸锂治疗,观察组采用碳酸锂联合奥氮平治疗,比较两组患者的总有效率、血清同型半胱氨酸水平、血尿酸水平、躁狂评分、抑郁评分、焦虑评分、注意力评分、认知功能评分、社会功能评分、不良反应发生率。结果:观察组总有效率为96.67%,高于对照组的80.00%(P<0.05);观察组血清同型半胱氨酸水平、血尿酸水平低于对照组(P<0.05);观察组躁狂评分、抑郁评分、焦虑评分低于对照组(P<0.05);观察组注意力评分、认知功能评分、社会功能评分高于对照组(P<0.05);观察组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥氮平与碳酸锂联合治疗双相情感障碍的疗效显著,不仅可有效降低血清同型半胱氨酸、血尿酸水平,控制躁狂发作,减轻抑郁症状,还可增强患者的注意力,改善其认知功能和社会功能,且不良反应少,用药安全性良好。

Objective: To explore the effect of olanzapine combined with lithium carbonate in the treatment of bipolar disorder. Methods: A total of 60 patients with bipolar disorder admitted to the psychiatric department of our hospital from January 2019 to January 2021 were selected as the research objects. According to the random number table method, they were divided into control group(30 cases) and observation group(30 cases). The control group was treated with lithium carbonate,and the observation group was treated with lithium carbonate combined with olanzapine. The total effective rate, serum homocysteine level, serum uric acid level, mania score, depression score, anxiety score, attention score, cognitive function score, social function score, and incidence of adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was 96.67%, which was higher than 80.00% of the control group(P<0.05). The serum homocysteine level and serum uric acid level in the observation group were lower than those in the control group(P<0.05).The scores of mania, depression and anxiety in the observation group were lower than those in the control group(P<0.05).The attention score, cognitive function score and social function score of the observation group were higher than those of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). Conclusion: Olanzapine combined with lithium carbonate is effective in the treatment of bipolar disorder. It can not only effectively reduce the levels of serum homocysteine and serum uric acid, control manic episodes, reduce depressive symptoms, but also enhance the attention of patients, improve their cognitive function and social function, with fewer adverse reactions and good drug safety.