艾司奥美拉唑药物的不良反应及相关因素分析

Analysis of Adverse Reactions and Related Factors of Esomeprazole

目的:探讨艾司奥美拉唑药物的不良反应,分析出现不良反应的相关因素。方法:收集2019年2月—2022年2月本院就诊的300例接受艾司奥美拉唑药物治疗患者的临床资料,分析不良反应情况及年龄、性别、给药途径、联合用药分布情况,并采用单因素和多因素分析不良反应的影响因素。结果:300例接受艾司奥美拉唑药物治疗患者中有96例出现不良反应,以中年与老年人数居多,男性患者多于女性患者,口服给药出现不良反应占比高于注射给药,联合用药出现不良反应占比高于单独用药。单因素分析显示,年龄、联合用药与不良反应有关(P<0.05);多因素Logistic回归分析显示,年龄>35岁、联合用药是不良反应的独立危险因素(P<0.05)。结论:年龄增长、联合用药会导致患者出现的不良反应增多,临床要重视艾司奥美拉唑的使用方法,保证合理用药。

Objective: To investigate the adverse reactions of esomeprazole and analyze the related factors of adverse reactions. Methods: The clinical data of 300 patients treated with esomeprazole in our hospital from February 2019 to February 2022 were collected. The adverse reactions and the distribution of age, sex, route of administration and combination were analyzed, and the influencing factors of adverse reactions were analyzed by univariate and multivariate analysis.Results: Among 300 patients treated with esomeprazole, 96 patients had adverse reactions, most of them were middle-aged and elderly, and male patients were more than female patients. The proportion of adverse reactions of oral administration was higher than that of injection administration, and the proportion of adverse reactions of combined administration was higher than that of single administration. Univariate analysis showed that age and drug combination were associated with adverse reactions(P<0.05). Multivariate Logistic regression analysis showed that age>35 years and drug combination were independent risk factors for adverse reactions(P<0.05). Conclusion: The increase of age and the combination of drugs will lead to the increase of adverse reactions in patients. It is necessary to pay attention to the use of esomeprazole in clinical practice to ensure rational drug use.