用药护理在丙种球蛋白治疗新生儿败血症过程中的应用效果

The Effect of Medication Nursing in Gamma Globulin Treatment of Neonatal Sepsis

目的:探究用药护理在丙种球蛋白治疗新生儿败血症过程中的应用效果。方法:选取郑州市妇幼保健院2021年6月—2022年6月收治的60例新生儿败血症患儿,采用信封法将其分为对照组和观察组,各30例。两组患者均给予丙种球蛋白治疗,对照组行常规护理,观察组在常规护理基础上联合用药护理,比较两组护理疗效、症状改善时间、血清指标(CRP、PCT、杆状核中性粒细胞、总胆红素、NK细胞、血小板计数、IgG及IgM水平)及家属满意度。结果:观察组护理总有效率为93.33%,高于对照组的73.33%(P<0.05);观察组神经系统症状改善时间、体温改善时间、拒奶情况改善时间及住院时间均短于对照组(P<0.05);观察组血清CRP、PCT、杆状核中性粒细胞水平低于对照组(P<0.05);观察组胆红素水平低于对照组,NK细胞、血小板计数、IgG及IgM水平高于对照组(P<0.05);观察组患儿家属满意度高于对照组(P<0.05)。结论:用药护理可提升新生儿败血症患儿应用丙种球蛋白治疗的效果,缓解临床症状,降低炎症因子水平,改善免疫功能,且家属满意度较高。

Objective: To explore the effect of medication nursing in gamma globulin treatment of neonatal sepsis. Methods:Sixty neonates with sepsis admitted to Zhengzhou Maternal and Child Health Hospital from June 2021 to June 2022 were selected and divided into control group and observation group by envelope method, with 30 cases in each group. Both groups of patients were given gamma globulin treatment, the control group received routine nursing, and the observation group was combined with medication nursing on the basis of routine nursing. The nursing efficacy, symptom improvement time,serum indicators(CRP, PCT, rod nucleus neutrophils, total bilirubin, NK cells, platelet count, IgG and IgM levels) and family satisfaction were compared between the two groups. Results: The total effective rate of nursing in the observation group was 93.33%, which was higher than 73.33% in the control group(P<0.05). The improvement time of neurological symptoms,body temperature, milk refusal and hospitalization time in the observation group were shorter than those in the control group(P<0.05). The levels of serum CRP, PCT and neutrophil in the observation group were lower than those in the control group(P<0.05). The level of bilirubin in the observation group was lower than that in the control group, and the levels of NK cells,platelet count, IgG and IgM were higher than those in the control group(P<0.05). The family satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion: Medication nursing can improve the effect of gamma globulin treatment in children with neonatal sepsis, relieve clinical symptoms, reduce the level of inflammatory factors,improve immune function, and have higher family satisfaction.