外用5%米诺地尔酊联合二氧化碳点阵激光治疗斑秃的疗效观察

目的 探讨外用5%米诺地尔酊联合二氧化碳点阵激光治疗斑秃(AA)的疗效及安全性.方法 选择AA患者90例,随机分为观察组和对照组各45例.观察组采用外用5%米诺地尔酊联合二氧化碳点阵激光治疗,对照组采用外用5%米诺地尔酊治疗.疗程4个月,随访6个月.比较两组有效率、治愈率、不良反应及复发率.结果 两组患者治疗4个月后,观察组有效率91.0%,治愈率60.0%,对照组有效率73.0%,治愈率55.6%.两组有效率比较差异有统计学意义(P<0.05).至随访结束,观察组复发率2.22%,对照组复发率17.78%.两组复发率比较差异有统计学意义(P<0.05).两组患者均未出现明显不良反应.结论 外用5%米诺地尔酊联合点阵激光治疗AA可以提高疗效,不良反应少,疗效较为持续,值得推广.

ObjectiveTo investigate the clinical eficacy and safety profile of topical 5%minoxidil solution combined with fractional carbon dioxide laser in treating alopecia areata(AA).Methods 90 patients with alopecia areata were randomly allocated into 2 groups:45 cases in the trial group treated with topical 5%minoxidil solution combined with fractional carbon dioxide laser and 45 cases in the control group treated with topical 5%minoxidil solution.The efficacy,adverse reactions and short-term recurrence rate were observed after 4 months of treatment and 6 months follow-up.ResultsAfter 4 months of the treatment,the total effective rate and the curative rate in the trial group were 91.0%and 60.0%,respectively,while the effective rate and the curative rate in the control group were 73.0%and 55.6%respectively.There was a significant dference in effective rate between the trial group and the control group(P<0.05).After 6 months follow-up,the recurrence rates in the trial group and control group were 2.27%and 18.60%,respectively(P<0.05 between the two groups).No serious side-effects were observed in either group during the treatment.Conclusion Topical 5%minoxidil solution combined with fractional carbon dioxide laser is a safe and effective treatment for alopecia areata.It is worthy of clinical application and promotion.