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肝糖原与代谢相关性脂肪性肝病的关系研究进展

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摘要 代谢相关性脂肪性肝病(metabolic dysfunction-associated fatty liver disease,MAFLD),前身为非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD),常伴有代谢综合征的因素,如糖尿病、肥胖症和高脂血症等,目前已成为最常见的慢性肝病,影响世界范围内约1/4的成年人口.MAFLD是一种因脂肪在肝脏实质细胞过度积聚,导致肝功能损害的疾病.此外,MAFLD最常见的是肝脏代谢动态平衡的失调引起脂质和碳水化合物代谢紊乱,从而进一步致使MAFLD进展为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、肝硬化,甚至肝癌.在这一系列疾病谱变化中,糖原代谢作为碳水化合物代谢的关键部分,在MAFLD的发展过程中起着不可或缺的作用.本文对肝脏糖原代谢及糖原结构的特点,及肝糖原代谢在MAFLD发生发展中的重要作用作如下综述.
出处 《浙江临床医学》 2023年第2期298-300,共3页 Zhejiang Clinical Medical Journal
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